Publication:
Incidence of zika virus infection from a dengue epidemiological study of children in ratchaburi province, thailand

dc.contributor.authorPimolpachr Sriburinen_US
dc.contributor.authorPichamon Sittikulen_US
dc.contributor.authorNathamon Kosoltanapiwaten_US
dc.contributor.authorSalin Sirinamen_US
dc.contributor.authorWatcharee Arunsodsaien_US
dc.contributor.authorChukiat Sirivichayakulen_US
dc.contributor.authorKriengsak Limkittikulen_US
dc.contributor.authorSupawat Chatchenen_US
dc.contributor.otherFaculty of Tropical Medicine, Mahidol Universityen_US
dc.date.accessioned2022-08-04T08:48:12Z
dc.date.available2022-08-04T08:48:12Z
dc.date.issued2021-09-01en_US
dc.description.abstractZika virus (ZIKV) is the mosquito-transmitted virus that the WHO declared a Public Health Emergency of International Concern in 2016 due to the consequence of microcephaly from infected pregnancies. The incidence of Zika infection has been unclear in many countries because most infected people have nonspecific febrile illnesses. This study’s aim is to investigate the incidence of symptomatic Zika virus infections from the archived samples of a dengue cohort study of children in central Thailand from 2006 to 2009. We performed Zika NS1 immunoglobulin (Ig)G enzyme-linked immunosorbent assay (ELISA) screening to identify symptomatic Zika infections in paired acute/convalescent serum samples. Symptomatic Zika infections were confirmed by reverse transcription polymerase chain reactions (RT-PCR) of acute serum samples. The comparison of the Zika NS1 IgG ELISA results between acute and convalescent samples showed 290/955 (30.4%) seropositive cases. Zika RT-PCR results were positive in 28 febrile cases (15 females, 13 males). Zika RT-PCR showed that symptomatic Zika infection occurred in children aged 4–11 years in Ratchaburi province, Thailand (2007–2009, first case in April 2007), and the symptomatic Zika:dengue infection ratio was 28 Zika:394 dengue (1:14). Phylogenetic analysis showed that all Zika viruses were of Asian lineage. Zika NS1 IgG ELISA identified Zika-infected patients and showed a low Zika:dengue ratio.en_US
dc.identifier.citationViruses. Vol.13, No.9 (2021)en_US
dc.identifier.doi10.3390/v13091802en_US
dc.identifier.issn19994915en_US
dc.identifier.other2-s2.0-85115065358en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/77228
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85115065358&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleIncidence of zika virus infection from a dengue epidemiological study of children in ratchaburi province, thailanden_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85115065358&origin=inwarden_US

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