Publication:
SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA

Issued Date

1988-07-09

Resource Type

Article

ISSN

01406736

DOI

10.1016/S0140-6736(88)90002-5

Other identifier(s)

2-s2.0-0023905618

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

The Lancet. Vol.332, No.8602 (1988), 64-66

Suggested Citation

N. J. White, R. E. Phillips, S. Looareesuwan, P. Chanthavanich, D. A. Warrell SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA. The Lancet. Vol.332, No.8602 (1988), 64-66. doi:10.1016/S0140-6736(88)90002-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15611

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Title

SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA

Author(s)

N. J. White
 R. E. Phillips
 S. Looareesuwan
 P. Chanthavanich
 D. A. Warrell

Other Contributor(s)

Mahidol University
 Nuffield Department of Clinical Medicine

Abstract

48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3·5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12·5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria. © 1988.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/15611

Collections

Scopus 1969-1990