Publication: SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA
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1988-07-09
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01406736
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2-s2.0-0023905618
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Mahidol University
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SCOPUS
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The Lancet. Vol.332, No.8602 (1988), 64-66
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N. J. White, R. E. Phillips, S. Looareesuwan, P. Chanthavanich, D. A. Warrell SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA. The Lancet. Vol.332, No.8602 (1988), 64-66. doi:10.1016/S0140-6736(88)90002-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15611
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SINGLE DOSE PHENOBARBITONE PREVENTS CONVULSIONS IN CEREBRAL MALARIA
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48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3·5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12·5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria. © 1988.