Publication: The molecular basis of AE-bart's disease
| dc.contributor.author | V. Thonglairuam | en_US |
| dc.contributor.author | P. Winichagoon | en_US |
| dc.contributor.author | S. Fucharoen | en_US |
| dc.contributor.author | P. Wasi | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-06-14T09:13:00Z | |
| dc.date.available | 2018-06-14T09:13:00Z | |
| dc.date.issued | 1989-01-01 | en_US |
| dc.description.abstract | AE-Bart's disease is a thalassemia intermedia resulting from the interaction between αthalassemia and heterozygous Hb E. In this study we analyzed the αglobin genes of 25 patients designated as AE-Bart's disease by starch gel electrophoresis. Twenty-one cases had Hb Constant Spring in addition to Hbs E + A + Bart's, and the remaining four cases had only Hbs E + A + Bart's. DNA mapping revealed the αglobin genotype of αthalassemia-1/αthalas-semia-2 in four patients who had Hbs E + A + Bart's, whereas the α genotype of the remainder is αthalassemia-1/nondeletion αthalassemia. The nondeletion αthalassemia is Hb Constant Spring as indicated by starch gel electrophoresis. Hematologic data and hemoglobin analysis showed that Constant Spring-AE-Bart's disease is a more severe clinical syndrome than AE-Bart's disease. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. | en_US |
| dc.identifier.citation | Hemoglobin. Vol.13, No.2 (1989), 117-124 | en_US |
| dc.identifier.doi | 10.3109/03630268908998061 | en_US |
| dc.identifier.issn | 03630269 | en_US |
| dc.identifier.other | 2-s2.0-0024549950 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/15726 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024549950&origin=inward | en_US |
| dc.subject | Biochemistry, Genetics and Molecular Biology | en_US |
| dc.subject | Medicine | en_US |
| dc.title | The molecular basis of AE-bart's disease | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024549950&origin=inward | en_US |