Publication: Comparative study of LDL-cholesterol levels in Thai patients by the direct method and using the Friedewald formula
2
Issued Date
2007-05-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-34547351701
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.38, No.3 (2007), 519-527
Suggested Citation
Thirawuth Teerakanchana, Wilai Puavilai, Kanjana Suriyaprom, Rungsunn Tungtrongchitr Comparative study of LDL-cholesterol levels in Thai patients by the direct method and using the Friedewald formula. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.38, No.3 (2007), 519-527. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24904
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Comparative study of LDL-cholesterol levels in Thai patients by the direct method and using the Friedewald formula
Other Contributor(s)
Abstract
In this study, low-density lipoprotein cholesterol (LDL-C) levels by direct measurement and estimation using the Friedewald formula, were compared among 1,016 Thai patients, The study assessed blood samples from out-patients sent to the Clinical Chemistry Laboratory, Department of Clinical Pathology, Rajvithi Hospital, Ministry of Public Health, for measurement of total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, January 2004-December 2005. Patients' ages ranged 8-89 years, 573 (56.4%) were females. Linear regression analysis showed the two methods had highly significant correlation coefficients (p<0.001). Upon comparing the two methods, at TG levels of 151-200mg/dl, bias was 18.3mg/dl; and for TG levels of 201-300 mg/dl, bias was lower at 11.4 mg/dl; for TG levels of 301-400 mg/dl, bias increased to 20.9 mg/dl. The direct assay meets currently established analytical performance targets and may be useful for the diagnosis and management of hyperlipidemic patients. The Friedewald formula did not give a homogeneous performance when estimating LDL-C levels in samples with different TG levels.