Publication: Enhanced hepatotoxicity of aflatoxin B<inf>1</inf> by pretreatment of rats with ethanol
Issued Date
1982-01-01
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ISSN
00345164
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2-s2.0-0019974501
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Mahidol University
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SCOPUS
Bibliographic Citation
Research Communications in Chemical Pathology and Pharmacology. Vol.36, No.3 (1982), 477-491
Suggested Citation
C. Toskulkao, S. Taycharpipranai, T. Glinsukon Enhanced hepatotoxicity of aflatoxin B<inf>1</inf> by pretreatment of rats with ethanol. Research Communications in Chemical Pathology and Pharmacology. Vol.36, No.3 (1982), 477-491. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30413
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Title
Enhanced hepatotoxicity of aflatoxin B<inf>1</inf> by pretreatment of rats with ethanol
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Abstract
Hepatotoxicity of aflatoxin B1 (2.0 and 4.0 mg/kg i.p.) as determined by plasma enzyme activities (GPT and GOT), liver triglycerides and histopathologic changes was enhanced in rats pretreated with four oral doses of ethanol (4.0 g/kg each) at 48, 45, 24 and 21 hrs prior to aflatoxin B1 administration. Pretreatment with ethanol (4.0 g/kg) slightly increased liver weight without changing hepatic microsomal protein contents. Also it caused an increase in microsomal aniline hydroxylase but a decrease in p-nitroanisole-o-demethylase, 48 hrs after the first ethanol dose. In the rats pretreated with ethanol, aflatoxin B1 was metabolized at a higher extent to aflatoxins M1 and Q1. These results suggest that an increased hepatotoxicity of aflatoxin B1 after pretreatment with ethanol may presumably be due to an increase in microsomal formation of active aflatoxin B1 metabolite.