Publication: Molecularly imprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond
Issued Date
2006-02-15
Resource Type
ISSN
10974628
00218995
00218995
Other identifier(s)
2-s2.0-33645140905
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Applied Polymer Science. Vol.99, No.4 (2006), 1390-1398
Suggested Citation
Somchai Boonpangrak, Virapong Prachayasittikul, Leif Bülow, Lei Ye Molecularly imprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond. Journal of Applied Polymer Science. Vol.99, No.4 (2006), 1390-1398. doi:10.1002/app.22519 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23387
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Molecularly imprinted polymer microspheres prepared by precipitation polymerization using a sacrificial covalent bond
Other Contributor(s)
Abstract
Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model, cholesteryl (4-vinyl)phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as crosslinker. The base-labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis, and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB crosslinker had larger and more defined spherical shape, and displayed better imprinting effect than did the EDMA-based microparticles. For compar ison, imprinted bulk polymers were also prepared in the same reaction solvent as that used in precipitation polymerization. Elemental analysis results indicated that imprinted microspheres contained more template monomer units than bulk materials. The efficiency of template removal by hydrolysis treatment for microspheres was also higher than that for bulk polymers. For DVB-based polymers, imprinted microspheres displayed higher specific cholesterol uptake than did the corresponding bulk polymer. © 2005 Wiley Periodicals, Inc.