Publication: Paroxysmal neuromyotonia: A new sporadic channelopathy
Issued Date
2012-06-01
Resource Type
ISSN
18732364
09608966
09608966
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2-s2.0-84860570471
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuromuscular Disorders. Vol.22, No.6 (2012), 479-482
Suggested Citation
Teeratorn Pulkes, Charungthai Dejthevaporn, Metha Apiwattanakul, Chutima Papsing, Michael G. Hanna Paroxysmal neuromyotonia: A new sporadic channelopathy. Neuromuscular Disorders. Vol.22, No.6 (2012), 479-482. doi:10.1016/j.nmd.2012.01.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14795
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Title
Paroxysmal neuromyotonia: A new sporadic channelopathy
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Abstract
Neuromyotonia is a heterogeneous group of genetic and autoimmune channelopathies resulting in hyperexcitability of peripheral nerves. We report an unusual case of neuromyotonia, which to our knowledge has not been previously described. The patient developed intermittent attacks of severe painful muscle stiffness accompanied by sweating, myokymia and raised serum creatine kinase. Genetic analysis of KCNA1, KCNQ2 and SCN4A genes did not identify pathogenic mutation. Serum voltage-gated potassium channel antibody was also negative. He was successfully treated with acetazolamide and carbamazepine. This appears to be a new neuromuscular disease, "paroxysmal neuromyotonia", the etiology of which is still unknown. © 2012 Elsevier B.V.