Publication: Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria
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Issued Date
1994-01-01
Resource Type
ISSN
00034983
Other identifier(s)
2-s2.0-0028048187
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Tropical Medicine and Parasitology. Vol.88, No.4 (1994), 359-363
Suggested Citation
P. Wilairatana, S. Looareesuwan Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria. Annals of Tropical Medicine and Parasitology. Vol.88, No.4 (1994), 359-363. doi:10.1080/00034983.1994.11812877 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9588
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Title
Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria
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Abstract
The efficacy of indomethacin and acetaminophen as antipyretics was compared in 43 febrile patients with uncomplicated falciparum malaria. Each patient was randomly assigned to receive low oral doses of indomethacin (25 mg three times a day) or acetaminophen (1000 mg four times a day) as well as mefloquine. Oral temperature was measured before dosing and then every 4h until apyrexia. Indomethacin was significantly quicker at clearing fever than acetaminophen (P < 0.05) and at reducing excessively high fever (≥39°C) to a safer range ( < 39°C). No adverse effects were observed in either treatment group. The study shows that indomethacin is a potent antipyretic agent. It appears to be a safe alternative to acetaminophen for the treatment of febrile malarial patients who may benefit from antipyretic medication, including those unresponsive to treatment with acetaminophen.