Publication: The metabolism of radioactive crustaxanthin (3,3′,4,4′-tetrahydroxy-β-carotene)
Issued Date
1975-03-15
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ISSN
03050491
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2-s2.0-0016662750
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Mahidol University
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SCOPUS
Bibliographic Citation
Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.50, No.3 (1975), 363-368
Suggested Citation
Jariya Boonjawat, James Allen Olson The metabolism of radioactive crustaxanthin (3,3′,4,4′-tetrahydroxy-β-carotene). Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.50, No.3 (1975), 363-368. doi:10.1016/0305-0491(75)90242-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/10741
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Title
The metabolism of radioactive crustaxanthin (3,3′,4,4′-tetrahydroxy-β-carotene)
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Abstract
1. 1. Tritiated crustaxanthin (3,3′,4,4′-tetrahydroxy-β-carotene), presumably labeled in the 4 and 4′-H positions, was prepared from astaxanthin (3,3′-dihydroxy-4,4′-diketo-β-carotene) by reduction with sodium borotritiide (NaB 3 H 4 ). 2. 2. Less than 0·4% of the tritium in crustaxanthin exchanged with water during equilibration in neutral aqueous solution. 3. 3. When 3 H-crustaxanthin was injected intraperitoneally into rats, most of the radioactivity was excreted in the urine as metabolites more polar than crustaxanthin, and a less polar radioactive metabolite was identified in the liver. 4. 4. Vitamin A was not labeled, and water of the urine contained a small but significant amount of tritium 5. 5. In the carp (Cyprinus carpio L.) 3 H-crustaxanthin given by intraperitoneal injection was absorbed efficiently, but was not metabolized to any detectable radioactive compounds. © 1975.