Publication: Transmission-blocking activities of quinine, primaquine, and artesunate
Issued Date
2006-06-01
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ISSN
00664804
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2-s2.0-33744480774
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Mahidol University
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SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.50, No.6 (2006), 1927-1930
Suggested Citation
Kesinee Chotivanich, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Sornchai Looareesuwan, Nicholas P.J. Day, Russell E. Coleman, Nicholas J. White Transmission-blocking activities of quinine, primaquine, and artesunate. Antimicrobial Agents and Chemotherapy. Vol.50, No.6 (2006), 1927-1930. doi:10.1128/AAC.01472-05 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23735
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Title
Transmission-blocking activities of quinine, primaquine, and artesunate
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Abstract
The infectivity of Plasmodium falciparum gametocytes after exposure in vitro to quinine, artesunate, and primaquine was assessed in Anopheles dims, a major vector of malaria in Southeast Asia. Mature gametocytes (stage 5) of a Thai isolate of P. falciparum were exposed to the drugs for 24 h in vitro before membrane feeding to A, dirus. After 10 days, the mosquito midguts were dissected and the oocysts were counted. In this system, artesunate showed the most potent transmission-blocking activity; the mean (standard deviation [SD]) 50% and 90% effective concentrations (EC50, and EC90, respectively, in nanograms per milliliter) were 0.1 (0.02) and 0.4 (0.15), respectively. Transmission-blocking activity of quinine and primaquine was observed at relatively high concentrations (SDs): EC50 of quinine, 642 (111) ng/ml; EC50 of primaquine, 181 (23) ng/ml; EC90 of quinine, 816 (96) ng/ml; EC90 of primaquine, 543 (43) ng/ml. Artesunate both prevents the maturation of immature P. falciparum gametocytes and reduces the transmission potential of mature gametocytes. Both of these effects may contribute to reducing malaria transmission. Copyright © 2006, American Society for Microbiology. All Rights Reserved.