Publication: Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand
Issued Date
2002-08-15
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ISSN
00221899
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2-s2.0-0037103603
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.186, No.4 (2002), 578-581
Suggested Citation
Jun Ohashi, Izumi Naka, Jintana Patarapotikul, Hathairad Hananantachai, Sornchai Looareesuwan, Katsushi Tokunaga Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand. Journal of Infectious Diseases. Vol.186, No.4 (2002), 578-581. doi:10.1086/341779 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20408
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Title
Significant association of longer forms of CCTTT microsatellite repeat in the inducible nitric oxide synthase promoter with severe malaria in Thailand
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Abstract
A CCTTT microsatellite repeat in the inducible nitric oxide synthase (iNOS) promoter was analyzed among 256 adult patients with severe Plasmodium falciparum malaria and 179 adult patients with mild malaria living in northwestern Thailand. Genotypes with longer forms of the CCTTT repeat (alleles of ≥15 repeats) were significantly associated with severe malaria (odds ratio [OR], 2.14; P = .0029, X2test). More interestingly, the summed repeat number of both microsatellite alleles in an individual was found to be a significant risk factor for severe malaria (OR, 1.11; logistic regression analysis, P = .0041). The single nucleotide substitution, -954G→C, in the iNOS promoter was rare in Thai patients with malaria. No variations were detected in the iNOS promoter region containing functional NF-κB elements at -5.2, -5.5, -5.8, and -6.1 kb upstream of the iNOS transcriptional start site. Thus, a CCTTT repeat in the iNOS promoter may play a key role in the pathogenesis of severe malaria.