Publication: Concurrent bilateral pheochromocytoma and thoracic paraganglioma during pregnancy
Issued Date
2010-04-01
Resource Type
ISSN
1355008X
Other identifier(s)
2-s2.0-77952098540
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Endocrine. Vol.37, No.2 (2010), 261-264
Suggested Citation
Thiti Snabboon, Wanee Plengpanich, Natnicha Houngngam, Patinut Buranasupkajorn, Nattachet Plengvidhya, Wisan Sereepapong, Sarat Sunthornyothin, Vorasuk Shotelersuk Concurrent bilateral pheochromocytoma and thoracic paraganglioma during pregnancy. Endocrine. Vol.37, No.2 (2010), 261-264. doi:10.1007/s12020-009-9292-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28747
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Concurrent bilateral pheochromocytoma and thoracic paraganglioma during pregnancy
Other Contributor(s)
Abstract
Although hypertension occurring during pregnancies is not uncommon and its prognosis is generally excellent, some of its unusual causes can lead to catastrophic consequences, especially in undiagnosed cases. Here, we report a pregnant woman who presented with hypertension in her early pregnancy. It was subsequently found to be caused by bilateral pheochromocytoma. After removal of both tumors, catecholamine levels unexpectedly and unexplainably remained elevated. At 23 weeks of gestation, the fetus was found dead in utero. After the fetal death, additional studies were performed and revealed a thoracic paraganglioma. To our knowledge, this is the first report of a case of three catecholamine-producing tumors occurring concurrently during a pregnancy. Genetic analysis helped identify this unprecedented condition; the patient harbored a heterozygous missense mutation c.482G>A in exon 3 of the VHL gene, indicating von Hippel-Lindau syndrome. Physicians who care for hypertensive pregnant patients should be aware of this condition as its diagnosis would probably lead to a better outcome. © 2009 Springer Science+Business Media, LLC.