Publication: Investigation on biological activities of anthranilic acid sulfonamide analogs
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Issued Date
2011-12-01
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ISSN
16112156
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2-s2.0-84855815989
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Mahidol University
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SCOPUS
Bibliographic Citation
EXCLI Journal. Vol.10, (2011), 155-161
Suggested Citation
Sutanun Doungsoongnuen, Apilak Worachartcheewan, Ratchanok Pingaew, Thummaruk Suksrichavalit, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul Investigation on biological activities of anthranilic acid sulfonamide analogs. EXCLI Journal. Vol.10, (2011), 155-161. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11231
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Title
Investigation on biological activities of anthranilic acid sulfonamide analogs
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Abstract
In the previous studies, the cytotoxicities of anthranilate sulfonamides were investigated. Herein, the bioactivities of 4-substituted (X = NO 2 , OCH 3 , CH 3 , Cl) benzenesulfonamides of anthranilic acid (5-8) are reported. The results revealed that all sulfonamides selectively exerted antifungal activity (25-50% inhibition) against C. albicans at 4 μg/mL. Furthermore, compounds 6 and 8 show antioxidative (SOD) activity. These sulfonamides, except for 6, selectively display cytotoxic effects toward MOLT-3 cells. It is interesting to note that sulfonamides with electron withdrawing substituent (5, X = NO 2 ) exhibited the highest cytotoxicity. This study provided preliminary structure-activity relationship of the anthranilic sulfonamides that is useful for further in-depth investigation.