Publication: Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes
Issued Date
2018-04-03
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ISSN
2162397X
21623945
21623945
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2-s2.0-85061112901
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Mahidol University
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SCOPUS
Bibliographic Citation
Adipocyte. Vol.7, No.2 (2018), 71-80
Suggested Citation
Chatchalit Rattarasarn Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes. Adipocyte. Vol.7, No.2 (2018), 71-80. doi:10.1080/21623945.2018.1429784 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46758
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Title
Dysregulated lipid storage and its relationship with insulin resistance and cardiovascular risk factors in non-obese Asian patients with type 2 diabetes
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Abstract
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. The prevalence of non-obese type 2 diabetes in Asians is up to 50%. This review aims to summarize the role of regional fat in the development of insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes as well as the role of intra-pancreatic fat and β-cell dysfunction. The body fat content of non-obese Asian type 2 diabetic patients is not different from that of non-diabetic subjects but the proportion of intra-abdominal and intra-hepatic fat are greater. Visceral fat contributes to insulin resistance and cardiovascular risk in non-obese Asian type 2 diabetes. Intra-hepatic fat and the hypertrophic abdominal subcutaneous adipocytes are associated with insulin resistance and cardiovascular risk in non-obese, non-diabetic Asian subjects. It may be true in non-obese Asian type 2 diabetic patients. The role of intra-myocellular lipid and insulin resistance is uncertain. Intra-pancreatic fat may not be involved in β-cell dysfunction in non-obese Asian type 2 diabetes.