Publication: Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans
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Issued Date
2016-01-01
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19420994
19420900
19420900
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2-s2.0-84989852267
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Mahidol University
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SCOPUS
Bibliographic Citation
Oxidative Medicine and Cellular Longevity. Vol.2016, (2016)
Suggested Citation
Wichit Suthammarak, Pornpayom Numpraphrut, Ratiya Charoensakdi, Neelobol Neungton, Vachara Tunrungruangtavee, Nattapon Jaisupa, Suwit Charoensak, Primchanien Moongkarndi, Weerasak Muangpaisan Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans. Oxidative Medicine and Cellular Longevity. Vol.2016, (2016). doi:10.1155/2016/1293036 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43151
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Title
Antioxidant-Enhancing Property of the Polar Fraction of Mangosteen Pericarp Extract and Evaluation of Its Safety in Humans
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Abstract
© 2016 Wichit Suthammarak et al. Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines. Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction. Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans. In this study, we investigated the safety of oral administration of the polar fraction of ME in 11 healthy Thai volunteers. During a 24-week period of the study, only minor and tolerable side effects were reported; no serious side effects were documented. Blood chemistry studies also showed no liver damage or kidney dysfunction in all subjects. We also demonstrated antioxidant property of the polar fraction of ME both in vitro and in vivo. Interestingly, oral administration of the polar fraction of ME enhanced the antioxidant capability of red blood cells and decreased oxidative damage to proteins within red blood cells and whole blood.