Publication: Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC
Issued Date
1998-04-29
Resource Type
ISSN
00099147
Other identifier(s)
2-s2.0-14444283108
Rights
Mahidol University
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SCOPUS
Bibliographic Citation
Clinical Chemistry. Vol.44, No.4 (1998), 740-748
Suggested Citation
Suthat Fucharoen, Pranee Winichagoon, Raewadee Wisedpanichkij, Busara Sae-Ngow, Rungrat Sriphanich, Warangkana Oncoung, Wanna Muangsapaya, Jew Chowthaworn, Sujin Kanokpongsakdi, Ahnond Bunyaratvej, Anong Piankijagum, Chris Dewaele Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC. Clinical Chemistry. Vol.44, No.4 (1998), 740-748. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18303
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Title
Prenatal and postnatal diagnoses of thalassemias and hemoglobinopathies by HPLC
Abstract
The conventional approach to qualitative and quantitative analyses of hemoglobin (Hb) molecules for the diagnoses of hemoglobinopathies requires a combination of tests. We used an automated HPLC (VARIANT(TM)) system to study α-thalassemia and β-thalassemia syndromes in Thailand. The beta-thalassemia short program is applicable to the diagnosis of α-thalassemia and β- thalassemia disorders, including Hb H, EA Bart's disease, and EF Bart's disease, in adults, newborns, and fetuses. The system cannot quantify accurately certain Hb molecules, such as Hb H and Hb Bart's. The alpha- thalassemia short program was therefore developed and used to quantify Hb Bart's to detect α-thalassemia genotypes in cord blood. This automated HPLC system is an alternative approach to the diagnosis of complicated thalassemia syndromes in Thailand and Southeast Asia.