Publication:
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans

Issued Date

2007-09-01

Resource Type

Article

ISSN

15461718
10614036

DOI

10.1038/ng2111

Other identifier(s)

2-s2.0-34548348144

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Genetics. Vol.39, No.9 (2007), 1092-1099

Suggested Citation

Paul J. Norman, Laurent Abi-Rached, Ketevan Gendzekhadze, Daniel Korbel, Michael Gleimer, Don Rowley, Dan Bruno, Christine V.F. Carrington, Dasdayanee Chandanayingyong, Yih Hsin Chang, Catalina Crespí, Güher Saruhan-Direskeneli, Patricia A. Fraser, Kamran Hameed, Giorgi Kamkamidze, Kwadwo A. Koram, Zulay Layrisse, Nuria Matamoros, Joan Milà, Myoung Hee Park, Ramasamy M. Pitchappan, D. Dan Ramdath, Ming Yuh Shiau, Henry A.F. Stephens, Siske Struik, David H. Verity, Robert W. Vaughan, Dolly Tyan, Ronald W. Davis, Eleanor M. Riley, Mostafa Ronaghi, Peter Parham Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans. Nature Genetics. Vol.39, No.9 (2007), 1092-1099. doi:10.1038/ng2111 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24138

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Title

Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans

Author(s)

Paul J. Norman
 Laurent Abi-Rached
 Ketevan Gendzekhadze
 Daniel Korbel
 Michael Gleimer
 Don Rowley
 Dan Bruno
 Christine V.F. Carrington
 Dasdayanee Chandanayingyong
 Yih Hsin Chang
 Catalina Crespí
 Güher Saruhan-Direskeneli
 Patricia A. Fraser
 Kamran Hameed
 Giorgi Kamkamidze
 Kwadwo A. Koram
 Zulay Layrisse
 Nuria Matamoros
 Joan Milà
 Myoung Hee Park
 Ramasamy M. Pitchappan
 D. Dan Ramdath
 Ming Yuh Shiau
 Henry A.F. Stephens
 Siske Struik
 David H. Verity
 Robert W. Vaughan
 Dolly Tyan
 Ronald W. Davis
 Eleanor M. Riley
 Mostafa Ronaghi
 Peter Parham

Other Contributor(s)

Stanford University School of Medicine
 London School of Hygiene & Tropical Medicine
 University of The West Indies Trinidad and Tobago
 Mahidol University
 Chung Shan Medical University
 Hospital Universitario Son Espases
 Istanbul Tip Fakultesi
 Immune Disease Institute, Inc. Boston
 The Aga Khan University Hospital
 Rea Rehabilitation Centre
 University of Ghana
 Instituto Venezolano de Investigaciones Cientificas
 Seoul National University College of Medicine
 Madurai Kamaraj University
 Hung Kuang University Taiwan
 UCL Medical School
 Moorfields Eye Hospital NHS Foundation Trust
 King's College London

Abstract

Interactions of killer cell immunoglobulin-like receptors (KIRs) with major histocompatibility complex (MHC) class I ligands diversify natural killer cell responses to infection. By analyzing sequence variation in diverse human populations, we show that the KIR3DL1/S1 locus encodes two lineages of polymorphic inhibitory KIR3DL1 allotypes that recognize Bw4 epitopes of protein">HLA-A and HLA-B and one lineage of conserved activating KIR3DS1 allotypes, also implicated in Bw4 recognition. Balancing selection has maintained these three lineages for over 3 million years. Variation was selected at D1 and D2 domain residues that contact HLA class I and at two sites on D0, the domain that enhances the binding of KIR3D to HLA class I. HLA-B variants that gained Bw4 through interallelic microconversion are also products of selection. A worldwide comparison uncovers unusual KIR3DL1/S1 evolution in modern sub-Saharan Africans. Balancing selection is weak and confined to D0, KIR3DS1 is rare and KIR3DL1 allotypes with similar binding sites predominate. Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression. © 2007 Nature Publishing Group.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24138

Collections

Scopus 2006-2010