Publication:
Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii

3

Issued Date

2002-09-01

Resource Type

Article

ISSN

01633864

DOI

10.1021/np020055+

Other identifier(s)

2-s2.0-0036743753

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Natural Products. Vol.65, No.9 (2002), 1346-1348

Suggested Citation

Namphung Vongvanich, Prasat Kittakoop, Masahiko Isaka, Srisuda Trakulnaleamsai, Saovaluk Vimuttipong, Morakot Tanticharoen, Yodhathai Thebtaranonth Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii. Journal of Natural Products. Vol.65, No.9 (2002), 1346-1348. doi:10.1021/np020055+ Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20048

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Title

Hirsutellide A, a new antimycobacterial cyclohexadepsipeptide from the entomopathogenic fungus Hirsutella kobayasii

Author(s)

Namphung Vongvanich
 Prasat Kittakoop
 Masahiko Isaka
 Srisuda Trakulnaleamsai
 Saovaluk Vimuttipong
 Morakot Tanticharoen
 Yodhathai Thebtaranonth

Other Contributor(s)

Mahidol University
 Thailand National Center for Genetic Engineering and Biotechnology

Abstract

A new cyclohexadepsipeptide, named hirsutellide A (1), was isolated from a cell extract of the entomopathogenic fungus Hirsutella kobayasii BCC 1660. The structure of 1 was elucidated by analyses of spectroscopic data, and its absolute stereochemistry was addressed by the use of Marfey's method. Hirsutellide A (1) exhibited antimycobacterial and antimalarial activities, but was inactive toward the Vero cell line (at 50 μg/mL).

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry
 Medicine
 Pharmacology, Toxicology and Pharmaceutics

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URI

https://repository.li.mahidol.ac.th/handle/123456789/20048

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Scopus 2001-2005