Publication: Androgenic activity of the Thai traditional male potency herb, Butea superba Roxb., in female rats
6
Issued Date
2009-01-12
Resource Type
ISSN
03788741
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2-s2.0-58049108364
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.121, No.1 (2009), 123-129
Suggested Citation
Suchinda Malaivijitnond, A. ngun Ketsuwan, Gen Watanabe, Kazuyoshi Taya, Wichai Cherdshewasart Androgenic activity of the Thai traditional male potency herb, Butea superba Roxb., in female rats. Journal of Ethnopharmacology. Vol.121, No.1 (2009), 123-129. doi:10.1016/j.jep.2008.10.014 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28332
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Title
Androgenic activity of the Thai traditional male potency herb, Butea superba Roxb., in female rats
Abstract
Aim of the study: Butea superba Roxb. (Leguminosae) is a well-known Thai male potency herb with androgenic and anti-estrogenic activities. We evaluated whether oral administration of Butea superba has an androgenic or anti-estrogenic activity in female rats. Materials and methods: Normal and ovariectomized adult female rats were each subdivided into five groups, DW, BS-10, BS-50, BS-250 and TP, and gavaged with 0, 10, 50 and 250 mg/kg BW/day of the crude of Butea superba and subcutaneously injected with 6 mg/kg BW/day of testosterone propionate (TP), respectively, during the treatment period. Results: In intact rats, only BS-250 increased the uterine thickness and the number of uterine glands, and could induce a prolonged diestrous phase. In ovariectomized rats, treatment with BS-50 as well as BS-250 increased the uterine thickness and the number of uterine glands. However, serum luteinizing hormone (LH) levels were also increased. TP reduced serum follicle stimulating hormone and LH levels with the appearance of anestrous cycle, and could significantly increase the relative uterine weight and thickness and the number of uterine glands in both intact and ovariectomized rats. Conclusions: Orally administered Butea superba tubers have an androgenic effect on the reproductive organs of intact and ovariectomized rats, and exhibit anti-estrogenic activity on LH secretion in ovariectomized rats. © 2008 Elsevier Ireland Ltd. All rights reserved.