Publication: Cerebral malaria
Issued Date
2000-01-01
Resource Type
ISSN
00223050
Other identifier(s)
2-s2.0-0033798212
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Neurology Neurosurgery and Psychiatry. Vol.69, No.4 (2000), 433-441
Suggested Citation
Charles R.J.C. Newton, Tran Tinh Hien, Nicholas White Cerebral malaria. Journal of Neurology Neurosurgery and Psychiatry. Vol.69, No.4 (2000), 433-441. doi:10.1136/jnnp.69.4.433 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26345
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Title
Cerebral malaria
Other Contributor(s)
Abstract
Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogenous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children. Recent studies have elucidated the molecular mechanisms of pathogenesis and raised possible interventions. Antimalarial drugs, however, remain the only intervention that unequivocally affects outcome, although increasing resistance to the established antimalarial drugs is of grave concern. Artemisinin derivatives have made an impact on treatment, but other drugs may be required. With appropriate antimalarial drugs, the prognosis of cerebral malaria often depends on the management of other complications - for example, renal failure and acidosis. Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments.