Publication: The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells
Issued Date
2021-06-01
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ISSN
22132198
Other identifier(s)
2-s2.0-85105015909
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Allergy and Clinical Immunology: In Practice. Vol.9, No.6 (2021), 2195-2208
Suggested Citation
Ana M. Giménez-Arnau, Laurence DeMontojoye, Riccardo Asero, Massimo Cugno, Kanokvalai Kulthanan, Yuhki Yanase, Michihiro Hide, Allen P. Kaplan The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells. Journal of Allergy and Clinical Immunology: In Practice. Vol.9, No.6 (2021), 2195-2208. doi:10.1016/j.jaip.2021.03.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78173
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Title
The Pathogenesis of Chronic Spontaneous Urticaria: The Role of Infiltrating Cells
Abstract
Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular infiltrate around small venules of the skin. It consists primarily of CD4(+) lymphocytes, a prominence of the T helper (Th)2 subtype but also Th1 cells, with Th17 cell–derived cytokines elevated in plasma. There are also neutrophils, eosinophils, basophils, and monocytes. Chemokines derived from mast cells and activated endothelial cells drive the process. Although the role of the cellular infiltrate has not previously been addressed, each constituent can contribute to the overall pathogenesis. It is of interest that CSU responds to corticosteroid, yet, short-term steroids do not affect autoimmunity or degranulation of mast cells, and act on margination of cells along the endothelium and chemotaxis to enter the surrounding dermis. In this review, we address each cell's contribution to the overall inflammatory response, as it is currently understood, with a view toward development of therapeutic options that impede the function of critical cells and/or their secretory products.