Publication: Eryngium foetidum suppresses inflammatory mediators produced by macrophages
Issued Date
2012-01-01
Resource Type
ISSN
2476762X
15137368
15137368
Other identifier(s)
2-s2.0-84866439608
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.13, No.2 (2012), 653-664
Suggested Citation
Chusana Mekhora, Channarong Muangnoi, Pimjai Chingsuwanrote, Suwitcha Dawilai, Saovaros Svasti, Kaimuk Chasri, Siriporn Tuntipopipat Eryngium foetidum suppresses inflammatory mediators produced by macrophages. Asian Pacific Journal of Cancer Prevention. Vol.13, No.2 (2012), 653-664. doi:10.7314/APJCP.2012.13.2.653 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13847
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Title
Eryngium foetidum suppresses inflammatory mediators produced by macrophages
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Abstract
Objective: This study assessed anti-inflammatory and antioxidant activities of E. foetidum leaf extract on LPS-activated murine macrophages. Methods: RAW264.7 cells were pretreated with or without E. foetidum extract for 1 h prior to incubation with LPS for 24 h. Anti-inflammatory activity was evaluated with reference to iNOS, COX-2, TNF-α and IL-6 geneexpression. In addition, NO and intracellular ROS generation were determined by Griess method and fluorescence intensityand activation of MAPKs and IkB by Western blotting. Results: Prior treatment with E. foetidum leaf extract inhibited elevation of IL-6, TNF-α, iNOS and COX-2, together with their cognate mRNAs in a dose-dependent manner. NO and intracellular ROS contents were similarly reduced. These effects were due to inhibition of LPS-induced phosphorylation of JNK and p38 as well as IκB. E. foetidum ethanol extract were shown to contain lutein, β-carotene, chlorogenic acid, kaempferol and caffeic acid, compounds known to exert these bioactive properties. Conclusions: E. foetidum leaf extract possesses suppressive effects against pro-inflammatory mediators. Thus, E. foetidum has a high potential to be used as a food supplement to reduce risk of cancer associated with inflammation.
