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Serum transforming growth factor-β1 and epidermal growth factor in biliary atresia

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dc.contributor.authorPaisarn Vejchapipaten_US
dc.contributor.authorA. Theamboonlersen_US
dc.contributor.authorS. Poomsawaten_US
dc.contributor.authorS. Chittmittrapapen_US
dc.contributor.authorY. Poovorawanen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherFaculty of Medicine, Thammasat Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-12T02:35:31Z
dc.date.available2018-07-12T02:35:31Z
dc.date.issued2008-12-01en_US
dc.description.abstractBackground and Aim: Biliary atresia (BA) is a serious liver disease in children. Since transforming growth factor-β1 (TGF-β1) and epidermal growth factor (EGF) are involved in the hepatic reparative process, our objective was to investigate whether serum TGF-β1 and serum EGF levels were associated with therapeutic outcomes in BA. Methods: Serum levels of TGF-β1 and EGF were determined with the ELISA method in 67 postoperative BA patients with a median age of 7 years and in 10 age-comparable healthy children. The BA patients were then divided into two groups depending on their therapeutic outcome: good outcome (jaundice-free) and poor outcome (persistent jaundice). Clinical data, serum TGF-β1 and serum EGF levels were compared between the two groups of BA patients. Correlation analysis of serum TGF-β1 with serum EGF was carried out. Data are expressed as mean ±SD. Results: Serum TGF-β1 levels of BA patients were higher than those of controls (86.6 ± 15.7 vs. 75.7 ± 8.8 ng/ml, p = 0.0362). However, there was no difference in serum EGF between BA patients and controls (133.1 ± 66.6 vs. 125.4 ± 88.9 pg/ ml, p=0.744). Further subgroup analysis showed that patients with good outcomes (n=40) had higher serum TGF-β1 and serum EGF levels than patients with poor outcomes (TGF-β1: 91.2 ± 16.5 vs. 79.6 ± 11.7 ng/ml, p = 0.002; EGF: 148.5 ± 65.0 vs. 110.3 ± 63.4 pg/ml, p = 0.02). In addition, serum TGF-β1 was positively correlated with serum EGF (Pearson's r = 0.3418, p = 0.0046). Conclusion: Elevated serum TGF-β1 and serum EGF levels were associated with a good outcome in BA patients. There was a positive correlation between serum TGF-β1 and serum EGF. This suggests that the resultant TGF-β1 and EGF pathways may be involved in the pathophysiological process in postoperative BA. © Georg Thieme Verlag KG Stuttgart.en_US
dc.identifier.citationEuropean Journal of Pediatric Surgery. Vol.18, No.6 (2008), 415-418en_US
dc.identifier.doi10.1055/s-2008-1038950en_US
dc.identifier.issn09397248en_US
dc.identifier.other2-s2.0-58149288001en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/19445
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149288001&origin=inwarden_US
dc.subjectMedicineen_US
dc.titleSerum transforming growth factor-β1 and epidermal growth factor in biliary atresiaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=58149288001&origin=inwarden_US
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