Publication: ZAP-70 Expression and its Prognostic Significance in Childhood B-lineage Acute Lymphoblastic Leukemia
Issued Date
2010
Resource Type
Language
eng
ISSN
0125-3611 (Print)
2651-0561 (Online)
2651-0561 (Online)
Rights
Mahidol University
Rights Holder(s)
Department of Pathology Faculty of Medicine Ramathibodi Hospital Mahidol University
Department of Pediatrics Queen Sirikit National Institute of Child Health
Samitivej Hospital. Pathology Unit
Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University
Department of Pediatrics Queen Sirikit National Institute of Child Health
Samitivej Hospital. Pathology Unit
Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University
Bibliographic Citation
Ramathibodi Medical Journal. Vol. 33, No. 3 (Jul-Sep 2010), 200-208
Suggested Citation
Karan Paisooksantivatana, Chanidapa Iamsa-art, ฺBenjawan Rungsimaporn, Somjai Kanjanapongkul, Surapon Worapongpaiboon, Samart Pakakasama, การันต์ ไพสุขศานติวัฒนา, ชนิดาภา เอี่ยมสอาด, เบญจวรรณ รังสิมาภรณ์, สมใจ กาญจนาพงศ์กุล, สุรพล วรพงศ์ไพบูลย์, สามารถ ภคกษมา ZAP-70 Expression and its Prognostic Significance in Childhood B-lineage Acute Lymphoblastic Leukemia. Ramathibodi Medical Journal. Vol. 33, No. 3 (Jul-Sep 2010), 200-208. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79868
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Title
ZAP-70 Expression and its Prognostic Significance in Childhood B-lineage Acute Lymphoblastic Leukemia
Other Contributor(s)
Abstract
Background: ZAP-70 expression was found in normal human B cell precursors and B lymphoproliferative disorders. Since the level of ZAP-70 expression is prognositic in chronic lymphocytic leukemia, a similar role may be demonstrable in other B-lineage malignancies. The present study investigates the expression of ZAP-70 in B-lineage acute lymphoblastic leukemia and its prognostic significance.
Methods: Thirty-three bone marrow and blood samples were obtained from children newly diagnosed with B-lineage ALL. ZAP-70 was determined using flow cytometry. Correlation between expression of ZAP-70 and clinicobiological presenting features (age, sex, white blood cells) and cytogenetics was performed.
Results: ZAP-70 was expressed in all cases with a wide variation (0.11 - 87.68%). There is no correlation between ZAP-70 expression level and clinicobiological presenting features also the cytogenetics abnormalities was found. Aberrantly high expression of ZAP-70 was found in three cases, two of which had aberrant CD13 and CD33 co-expression.
Conclusions: Aberrantly high expression of ZAP-70 might be associated with certain subgroup (CD13 and CD33 coexpression) of B-lineage ALL.