Publication:
Resistance of monocyte to HIV-1 infection is not due to uncoating defect

Issued Date

2007-06-01

Resource Type

Article

ISSN

01681702

DOI

10.1016/j.virusres.2007.02.016

Other identifier(s)

2-s2.0-34248143315

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Virus Research. Vol.126, No.1-2 (2007), 277-281

Suggested Citation

Sirawat Srichatrapimuk, Prasert Auewarakul Resistance of monocyte to HIV-1 infection is not due to uncoating defect. Virus Research. Vol.126, No.1-2 (2007), 277-281. doi:10.1016/j.virusres.2007.02.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24187

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Thesis

Title

Resistance of monocyte to HIV-1 infection is not due to uncoating defect

Author(s)

Sirawat Srichatrapimuk
 Prasert Auewarakul

Other Contributor(s)

Mahidol University

Abstract

Freshly isolated blood monocytes show an early postentry block to in vitro HIV-1 infection. Differentiation into monocyte-derived macrophages (MDMs) is required to allow HIV replication in this cell type. In this study, we investigated whether the resistance of monocyte to HIV infection stemmed from uncoating defect. Monocyte and MDM lysates induced HIV-1 core uncoating to a comparable degree. This suggests that monocyte lacks a factor(s) essential for viral reverse transcription and/or contains a factor(s) interfering with this step. © 2007 Elsevier B.V. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24187

Collections

Scopus 2006-2010