Publication: Assessment of baseline characteristics, glycemic control and oral antidiabetic treatment in Asian patients with diabetes: The Registry for Assessing OAD Usage in Diabetes Management (REASON) Asia study
Issued Date
2013-09-01
Resource Type
ISSN
17530407
17530393
17530393
Other identifier(s)
2-s2.0-84881549550
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Diabetes. Vol.5, No.3 (2013), 309-318
Suggested Citation
Apichati Vichayanrat, Bien J. Matawaran, Aris Wibudi, Hossain S. Ferdous, Azizul Hasan Aamir, Sanjay K. Aggarwal, Shailendra Bajpai Assessment of baseline characteristics, glycemic control and oral antidiabetic treatment in Asian patients with diabetes: The Registry for Assessing OAD Usage in Diabetes Management (REASON) Asia study. Journal of Diabetes. Vol.5, No.3 (2013), 309-318. doi:10.1111/1753-0407.12038 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32185
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Assessment of baseline characteristics, glycemic control and oral antidiabetic treatment in Asian patients with diabetes: The Registry for Assessing OAD Usage in Diabetes Management (REASON) Asia study
Abstract
Background: To assess baseline characteristics, glycemic control, and treatment with oral antidiabetic drugs (OAD) in type 2 diabetes mellitus (T2DM) patients. Methods: This multinational, observational study recruited patients ≥21 years of age who were newly diagnosed and/or treated with OAD monotherapy for <6 months but were inadequately controlled. In cross-sectional phase, data on demographics, medical history, diabetic complications and comorbidities, OAD treatment, glycosylated hemoglobin (HbA1c), and fasting blood glucose (FBG) were collected. In longitudinal phase evaluating 6-month follow-up of sulfonylurea (SU)-treated patients, additional data on reasons for not achieving HbA1c targets were collected. Results: Of 1487 patients (mean [±SD] age 52.0±11.6 years; 46.7% men; mean BMI 25.8±4.4kg/m2) recruited, 75.9% were newly diagnosed, 73.3% had central obesity, 43.8% had hypertension, and 60.5% had dyslipidemia. The mean HbA1c was 9.8±2.4%, and the mean FBG was 11.3±4.3mmol/L. At T0(baseline) and T6(month 6 visit), 99.8% (n=1066) and 97.1% (n=830) patients received SU, respectively. There was decrease from T0to T6in mean HbA1c (10.2% vs 7.3%, respectively; P<0.0001) and mean FBG (12.0 vs 7.6 mmol/L, respectively; P<0.0001). Number of patients with HbA1c <7% increased from T0(4.5%) to T6(46.8%). Reasons for not achieving target HbA1c included poor diabetes education (50.7%), non-compliance to OADs (21.4%), and fear of hypoglycemia (19.7%). Conclusion: Marked reductions in HbA1c and FBG are achievable in T2DM patients managed with OADs. However, patient education and compliance are important for achieving and maintaining treatment targets. © 2013 Wiley Publishing Asia Pty Ltd and Ruijin Hospital, Shanghai Jiaotong University School of Medicine.