Publication: Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children
Issued Date
2020-09-30
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ISSN
14712431
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2-s2.0-85092304273
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Mahidol University
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SCOPUS
Bibliographic Citation
BMC Pediatrics. Vol.20, No.1 (2020)
Suggested Citation
Kanjana Suriyaprom, Banchamaphon Pheungruang, Rungsunn Tungtrongchitr, Orn Uma Y. Sroijit Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children. BMC Pediatrics. Vol.20, No.1 (2020). doi:10.1186/s12887-020-02350-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/60078
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Title
Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children
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Abstract
© 2020 The Author(s). Background: Childhood obesity represents a serious global health crisis. Apelin and its receptor system are widely distributed throughout the central nervous system and have been demonstrated to serve a role modulating feeding behaviour and energy homeostasis. The purposes of this study were to examine apelin concentrations and anthropometric-cardiometabolic parameters in obese and non-obese children and to identify associations of APLN T-1860C and APLNR G212A polymorphisms with apelin levels and obesity among Thai children. Methods: This case-control study included an analysis of 325 Thai children: 198 children with obesity and 127 healthy non-obese children. Anthropometric-cardiometabolic variables and apelin concentration were measured. Genotyping of APLN T-1860C and APLNR G212A was performed using the polymerase chain reaction-restriction fragment length polymorphism technique. Results: The obese group had significantly lower apelin and HDL-C levels but significantly higher triglycerides and glucose (TyG) index values, TG/HDL-C ratio and TC/HDL-C ratio than the non-obese group (p < 0.01). Apelin level was negatively correlated with body size phenotypes and cardiometabolic parameters (p < 0.05). The APLN T-1860C polymorphism (OR = 4.39, 95% CI = 1.25-15.28) and apelin concentration (OR = 0.45, 95% CI = 0.23-0.92) were significantly associated with obesity among female children (p < 0.05) only, after adjusting for potential covariates. However, the APLNR G212A polymorphism showed no significant relationship with apelin concentration or obesity. Conclusion: These findings in Thai children suggest that apelin concentrations are related to obesity and cardiometabolic parameters. Furthermore, the APLN T-1860C polymorphism may influence susceptibility to obesity among female children.