Publication:
Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

Issued Date

2020-01-01

Resource Type

Article

ISSN

1573742X
09295305

DOI

10.1007/s11239-020-02180-x

Other identifier(s)

2-s2.0-85086853155

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Thrombosis and Thrombolysis. (2020)

Suggested Citation

Jeffrey I. Weitz, Sylvia Haas, Walter Ageno, Samuel Z. Goldhaber, Alexander G.G. Turpie, Shinya Goto, Pantep Angchaisuksiri, Jørn Dalsgaard Nielsen, Gloria Kayani, Alfredo E. Farjat, Sebastian Schellong, Henri Bounameaux, Lorenzo G. Mantovani, Paolo Prandoni, Ajay K. Kakkar, Ab Loualidi, Abdurrahim Colak, Abraham Bezuidenhout, Abu Abdool-Carrim, Addala Azeddine, Adriaan Beyers, Adriaan Dees, Ahmed Mohamed, Ahmet Aksoy, Akihiko Abiko, Akinori Watanabe, Alan Krichell, Alberto Alfredo Fernandez, Alberto Tosetto, Alexey Khotuntsov, Alisha Oropallo, Alison Slocombe, Allan Kelly, Amanda Clark, Amr Gad, Amy Arouni, Andor Schmidt, Andrea Berni, Andres Javier Kleiban, Andrew Machowski, Andrey Kazakov, Angel Galvez, Ann Lockman, Anna Falanga, Anoop Chauhan, Antoni Riera-Mestre, Antonino Mazzone, Armando D’Angelo, Artur Herdy, Atsushi Kato, Ayman Abd Elhamid Ebrahim Mahmoud Salem, Azlan Husin, Barbara Erdelyi, Barry Jacobson, Beatrice Amann-Vesti, Bektas Battaloglu, Benedicte Wilson, Benilde Cosmi, Bergmann Jean Francois, Berremeli Toufek, Beverley Hunt, Bhavesh Natha, Bisher Mustafa, Bonnie Chi Shan Kho, Boulon Carine, Brian Zidel, Brisot Dominique, Brousse Christophe, Bruno Trimarco, Canhua Luo, Carlos Alberto Cuneo, Carlos Jerjes Sanchez Diaz, Carsten Schwencke, Cas Cader, Celal Yavuz, Cesar Javier Zaidman, Charles Lunn, Chau Chung Wu, Cheng Hock Toh, Chern En Chiang, Chevrier Elisa, Chien Hsun Hsia, Chien Lung Huang, Chi Hang Kevin Kwok, Chih Cheng Wu, Chi Hung Huang, Chris Ward, Christian Opitz, Christina Jeanneret-Gris, Chung Yin Ha, Chun Yao Huang, Claude Luyeye Bidi, Clifford Smith, Cornelia Brauer, Corrado Lodigiani, Couturaud Francis, Cynthia Wu, Daniel Staub, Daniel Theodoro, Daniela Poli Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE. Journal of Thrombosis and Thrombolysis. (2020). doi:10.1007/s11239-020-02180-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58337

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Title

Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE

Author(s)

Jeffrey I. Weitz
 Sylvia Haas
 Walter Ageno
 Samuel Z. Goldhaber
 Alexander G.G. Turpie
 Shinya Goto
 Pantep Angchaisuksiri
 Jørn Dalsgaard Nielsen
 Gloria Kayani
 Alfredo E. Farjat
 Sebastian Schellong
 Henri Bounameaux
 Lorenzo G. Mantovani
 Paolo Prandoni
 Ajay K. Kakkar
 Ab Loualidi
 Abdurrahim Colak
 Abraham Bezuidenhout
 Abu Abdool-Carrim
 Addala Azeddine
 Adriaan Beyers
 Adriaan Dees
 Ahmed Mohamed
 Ahmet Aksoy
 Akihiko Abiko
 Akinori Watanabe
 Alan Krichell
 Alberto Alfredo Fernandez
 Alberto Tosetto
 Alexey Khotuntsov
 Alisha Oropallo
 Alison Slocombe
 Allan Kelly
 Amanda Clark
 Amr Gad
 Amy Arouni
 Andor Schmidt
 Andrea Berni
 Andres Javier Kleiban
 Andrew Machowski
 Andrey Kazakov
 Angel Galvez
 Ann Lockman
 Anna Falanga
 Anoop Chauhan
 Antoni Riera-Mestre
 Antonino Mazzone
 Armando D’Angelo
 Artur Herdy
 Atsushi Kato
 Ayman Abd Elhamid Ebrahim Mahmoud Salem
 Azlan Husin
 Barbara Erdelyi
 Barry Jacobson
 Beatrice Amann-Vesti
 Bektas Battaloglu
 Benedicte Wilson
 Benilde Cosmi
 Bergmann Jean Francois
 Berremeli Toufek
 Beverley Hunt
 Bhavesh Natha
 Bisher Mustafa
 Bonnie Chi Shan Kho
 Boulon Carine
 Brian Zidel
 Brisot Dominique
 Brousse Christophe
 Bruno Trimarco
 Canhua Luo
 Carlos Alberto Cuneo
 Carlos Jerjes Sanchez Diaz
 Carsten Schwencke
 Cas Cader
 Celal Yavuz
 Cesar Javier Zaidman
 Charles Lunn
 Chau Chung Wu
 Cheng Hock Toh
 Chern En Chiang
 Chevrier Elisa
 Chien Hsun Hsia
 Chien Lung Huang
 Chi Hang Kevin Kwok
 Chih Cheng Wu
 Chi Hung Huang
 Chris Ward
 Christian Opitz
 Christina Jeanneret-Gris
 Chung Yin Ha
 Chun Yao Huang
 Claude Luyeye Bidi
 Clifford Smith
 Cornelia Brauer
 Corrado Lodigiani
 Couturaud Francis
 Cynthia Wu
 Daniel Staub
 Daniel Theodoro
 Daniela Poli

Other Contributor(s)

Thrombosis & Atherosclerosis Research Institute
 IRCCS Multimedica
 McMaster University
 Tokai University School of Medicine
 University College London
 Technical University of Munich
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Copenhagen University Hospital
 Thrombosis Research Institute
 University of Milano - Bicocca
 Hôpitaux universitaires de Genève
 Università degli Studi dell'Insubria
 Harvard Medical School
 Municipal Hospital Dresden
 Arianna Foundation on Anticoagulation

Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Venous thromboembolism (VTE) is common in cancer patients and is an important cause of morbidity and mortality. The Global Anticoagulant Registry in the FIELD (GARFIELD)–VTE (ClinicalTrials.gov: NCT02155491) is a prospective, observational study of 10,684 patients with objectively diagnosed VTE from 415 sites in 28 countries. We compared baseline characteristics, VTE treatment patterns, and 1-year outcomes (mortality, recurrent VTE and major bleeding) in 1075 patients with active cancer, 674 patients with a history of cancer, and 8935 patients without cancer. Patients with active cancer and history of cancer were older than cancer-free patients, with median ages of 64.8, 68.9, and 58.4 years, respectively. The most common sites of active cancer were lung (14.5%), colorectal (11.0%), breast (10.6%), and gynaecological (10.3%). Active cancer patients had a higher incidence of upper limb and vena cava thrombosis than cancer-free patients (9.0% vs 4.8% and 5.1% vs 1.4%, respectively), and were more likely to receive parenteral anticoagulation as monotherapy than cancer-free patients (57.8% vs 12.1%), and less likely to receive DOACs (14.2% vs 50.6%). Rates of death, recurrent VTE, and major bleeding were higher in active cancer patients than in cancer-free patients, with hazard ratios (95% confidence intervals) of 14.2 (12.1–16.6), 1.6 (1.2–2.0) and 3.8 (2.9–5.0), respectively. VTE was the second most common cause of death in patients with active cancer or history of cancer. In patients with VTE, those with active cancer are at higher risk of death, recurrence, and major bleeding than those without cancer.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/58337

Collections

Scopus 2020