Publication: Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
Issued Date
2021-04-01
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ISSN
15387836
15387933
15387933
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2-s2.0-85100970494
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Thrombosis and Haemostasis. Vol.19, No.4 (2021), 1049-1063
Suggested Citation
Lonneke A. van Vught, Fabrice Uhel, Chao Ding, Cees van‘t Veer, Brendon P. Scicluna, Hessel Peters-Sengers, Peter M.C. Klein Klouwenberg, Peter Nürnberg, Olaf L. Cremer, Marcus J. Schultz, Tom van der Poll, Friso M. de Beer, Lieuwe D.J. Bos, Gerie J. Glas, Arie J. Hoogendijk, Roosmarijn T.M. van Hooijdonk, Janneke Horn, Mischa A. Huson, Laura R.A. Schouten, Marleen Straat, Luuk Wieske, Maryse A. Wiewel, Esther Witteveen, Marc J.M. Bonten, Olaf M. Cremer, David S.Y. Ong, Jos F. Frencken, Maria E. Koster-Brouwer, Kirsten van de Groep, Diana M. Verboom Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis. Journal of Thrombosis and Haemostasis. Vol.19, No.4 (2021), 1049-1063. doi:10.1111/jth.15246 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78321
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Title
Consumptive coagulopathy is associated with a disturbed host response in patients with sepsis
Author(s)
Lonneke A. van Vught
Fabrice Uhel
Chao Ding
Cees van‘t Veer
Brendon P. Scicluna
Hessel Peters-Sengers
Peter M.C. Klein Klouwenberg
Peter Nürnberg
Olaf L. Cremer
Marcus J. Schultz
Tom van der Poll
Friso M. de Beer
Lieuwe D.J. Bos
Gerie J. Glas
Arie J. Hoogendijk
Roosmarijn T.M. van Hooijdonk
Janneke Horn
Mischa A. Huson
Laura R.A. Schouten
Marleen Straat
Luuk Wieske
Maryse A. Wiewel
Esther Witteveen
Marc J.M. Bonten
Olaf M. Cremer
David S.Y. Ong
Jos F. Frencken
Maria E. Koster-Brouwer
Kirsten van de Groep
Diana M. Verboom
Fabrice Uhel
Chao Ding
Cees van‘t Veer
Brendon P. Scicluna
Hessel Peters-Sengers
Peter M.C. Klein Klouwenberg
Peter Nürnberg
Olaf L. Cremer
Marcus J. Schultz
Tom van der Poll
Friso M. de Beer
Lieuwe D.J. Bos
Gerie J. Glas
Arie J. Hoogendijk
Roosmarijn T.M. van Hooijdonk
Janneke Horn
Mischa A. Huson
Laura R.A. Schouten
Marleen Straat
Luuk Wieske
Maryse A. Wiewel
Esther Witteveen
Marc J.M. Bonten
Olaf M. Cremer
David S.Y. Ong
Jos F. Frencken
Maria E. Koster-Brouwer
Kirsten van de Groep
Diana M. Verboom
Abstract
Background: A prolonged prothrombin time (PT) is a common feature in sepsis indicating consumptive coagulopathy. Objectives: To determine the association between a prolonged PT and aberrations in other host response mechanisms in sepsis. Methods: Patients admitted to the intensive care unit with sepsis were divided in quartiles according to the highest PT value measured within 24 h after admission. The host response was evaluated by measuring 19 plasma biomarkers reflecting pathways implicated in sepsis pathogenesis and by blood leukocyte gene expression profiling. Measurements and Main Results: Of 1524 admissions for sepsis, 386 (25.3%) involved patients with a normal PT (≤12.7 s); the remaining quartiles entailed 379 (24.9%) patients with a slightly prolonged PT (12.8 ≤ PT ≤ 15.0 s), 383 (25.1%) with an intermediately prolonged PT (15.1 ≤ PT ≤ 17.2 s), and 376 (24.7%) with an extremely prolonged PT (≥17.3 s). While patients with an extremely prolonged PT showed an increased crude mortality up to 1 year after admission, none of the prolonged PT groups was independently associated with 30-day adjusted mortality. Comparison of the host response between patients with a normal PT or an extremely prolonged PT matched for baseline characteristics including severity of disease showed that an extremely prolonged PT was associated with impaired anticoagulant mechanisms, a more disturbed endothelial barrier integrity and increased systemic inflammation, and blood leukocyte transcriptomes indicating more prominent metabolic reprogramming and protein catabolism. Conclusion: A prolonged PT is associated with stronger anomalies in pathways implicated in the pathogenesis of sepsis, suggesting that activation of coagulation impacts other host response mechanisms.