Publication: Serum diazepam levels after oral administration in children
Issued Date
2002-11-01
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ISSN
01252208
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2-s2.0-0036881899
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.85, No.SUPPL. 4 (2002)
Suggested Citation
Anannit Visudtibhan, Surang Chiemchanya, Pongsakdi Visudhiphan, Auempa Kanjanarungsichai, Sming Kaojarern, Vorapun Pichaipat Serum diazepam levels after oral administration in children. Journal of the Medical Association of Thailand. Vol.85, No.SUPPL. 4 (2002). Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20331
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Title
Serum diazepam levels after oral administration in children
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Abstract
Objective: To determine serum levels of diazepam after oral administration in children. Patients and Method: Forty six children admitted with febrile seizures were orally administered with 0.25 mg/kg/dose of diazepam six hourly for four doses. Trough (prior to the next dose) and peak (at 1 hour 20 minutes after the dose) serum levels of diazepam were analyzed. The patients were observed for adverse effects of the medication. Results: The peak levels after 1st, 2nd, 3rd and 4th doses were above 0.15 μg/ml which is considered the therapeutic level in 93.5, 97.8, 97.7, and 100 per cent of the patients, respectively. The trough levels prior to the 2nd, 3rd, and 4th doses were greater than 0.15 μg/ml in 75.0, 84.0, and 91.3 per cent, respectively. Neither recurrent seizure nor serious adverse effects occurred in any of the patients. Conclusion: Serum concentrations above the therapeutic level were achieved after orally administered diazepam at 0.25 mg/kg/dose six hourly for four doses. Oral diazepam may be used as another method in the prevention of recurrent febrile seizures.