Publication: Homocysteine but not serum amyloid A, vitamin A and E related to increased risk of metabolic syndrome in post-menopausal thai women
Issued Date
2014-01-01
Resource Type
ISSN
16642821
03009831
03009831
Other identifier(s)
2-s2.0-84930176298
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal for Vitamin and Nutrition Research. Vol.84, No.1-2 (2014), 35-44
Suggested Citation
Kanjana Suriyaprom, Benjaluck Phonrat, Pratana Satitvipawee, Anchalee Tungtrongchitr, Rungsunn Tungtrongchitr Homocysteine but not serum amyloid A, vitamin A and E related to increased risk of metabolic syndrome in post-menopausal thai women. International Journal for Vitamin and Nutrition Research. Vol.84, No.1-2 (2014), 35-44. doi:10.1024/0300-9831/a000191 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34725
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Homocysteine but not serum amyloid A, vitamin A and E related to increased risk of metabolic syndrome in post-menopausal thai women
Other Contributor(s)
Abstract
© 2014 Hans Huber Publishers, Hogrefe AG, Bern. This study aims to investigate serum amyloid A, homocysteine, and biochemical-anthropometric measurements in post-menopausal women with and without metabolic syndrome (MS), and determine whether serum amyloid A and homocysteine are linked to MS among this group. This study was performed with 405 post-menopausal Thai volunteers with a mean age of 57.95 + 5.90 years (135 subjects with MS and 270 subjects without MS). The levels of serum amyloid A, homocysteine, vitamins, glucose, and lipids were measured. Homocysteine levels were significantly higher in the group with MS than in that without MS (p < 0.001), whereas for serum amyloid A, vitamin A, vitamin E and vitamin B12, there were no significant differences. There were significant differences between the groups in folate, HDL-C, and anthropometric measurements (p < 0.001). Thirty seven percent of the group with MS and 14.1 % of the group without MS were classified as having hyperhomocysteinemia (p < 0.001). Furthermore, logistic regression analysis revealed that hyperhomocysteinemia (odds ratio (OR): 2.67, 95 % confidence interval (95 %CI): 1.57 - 4.58), low folate (OR: 1.79, 95 %CI: 1.11 - 2.89), and BMI (OR: 1.25, 95 %CI: 1.16 - 1.33) were significantly related to MS. These findings suggest that increased homocysteine levels and decreased folate concentrations may influence susceptibility to MS and this effect may be an early event in the development of cardiovascular diseases among post-menopausal women. Therefore, there is a need to evaluate homocysteine levels, especially among post-menopausal Thai women.