Publication:
The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Issued Date

2008-08-22

Resource Type

Article

ISSN

14752875

DOI

10.1186/1475-2875-7-149

Other identifier(s)

2-s2.0-49649123369

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Malaria Journal. Vol.7, (2008)

Suggested Citation

Sue J. Lee, Kasia Stepniewska, Nicholas Anstey, Elizabeth Ashley, Karen Barnes, Tran Quang Binh, Umberto D'Alessandro, Nicholas P.J. Day, Peter J. De Vries, Grant Dorsey, Jean Paul Guthmann, Mayfong Mayxay, Paul Newton, Francois Nosten, Piero Olliaro, Lyda Osario, Loretxu Pinoges, Ric Price, Mark Rowland, Frank Smithuis, Robert Taylor, Nicholas J. White The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria. Malaria Journal. Vol.7, (2008). doi:10.1186/1475-2875-7-149 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19301

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malaria

Author(s)

Sue J. Lee
 Kasia Stepniewska
 Nicholas Anstey
 Elizabeth Ashley
 Karen Barnes
 Tran Quang Binh
 Umberto D'Alessandro
 Nicholas P.J. Day
 Peter J. De Vries
 Grant Dorsey
 Jean Paul Guthmann
 Mayfong Mayxay
 Paul Newton
 Francois Nosten
 Piero Olliaro
 Lyda Osario
 Loretxu Pinoges
 Ric Price
 Mark Rowland
 Frank Smithuis
 Robert Taylor
 Nicholas J. White

Other Contributor(s)

Mahidol University
 Royal Darwin Hospital
 Shoklo Malaria Research Unit
 University of Cape Town
 Choray Hospital
 Prins Leopold Instituut voor Tropische Geneeskunde
 Centre for Clinical Vaccinology and Tropical Medicine
 Academic Medical Centre, University of Amsterdam
 University of California, San Francisco
 Institut de Recherche en Sciences de la Santé
 Uganda Malaria Surveillance Program
 Epicentre
 National University of Laos
 University of Oxford
 Organisation Mondiale de la Sante
 Centro Internatcional de Entrenamiento e Investigaciones Medicas
 London School of Hygiene & Tropical Medicine

Abstract

Background. Malaria is a very important cause of anaemia in tropical countries. Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other. Methods. Data on patients with slide-confirmed uncomplicated falciparum malaria were pooled from 85 antimalarial drug trials conducted in 25 different countries, to assess the haemoglobin/haematocrit relationship at different time points in malaria. Using a linear random effects model, a conversion equation for haematocrit was derived based on 3,254 measurements from various time points (ranging from day 0 to day 63) from 1,810 patients with simultaneous measurements of both parameters. Haemoglobin was also estimated from haematocrit with the commonly used threefold conversion. Results. A good fit was obtained using Haematocrit = 5.62 + 2.60 * Haemoglobin. On average, haematocrit/3 levels were slightly higher than haemoglobin measurements with a mean difference (± SD) of -0.69 (± 1.3) for children under the age of 5 (n = 1,440 measurements from 449 patients). Conclusion. Based on this large data set, an accurate and robust conversion factor both in acute malaria and in convalescence was obtained. The commonly used threefold conversion is also valid. © 2008 Lee et al; licensee BioMed Central Ltd.

Keyword(s)

Immunology and Microbiology
 Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/19301

Collections

Scopus 2006-2010