Publication: Composition bias and genome polarity of RNA viruses
Issued Date
2005-01-01
Resource Type
ISSN
01681702
Other identifier(s)
2-s2.0-13844266895
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virus Research. Vol.109, No.1 (2005), 33-37
Suggested Citation
Prasert Auewarakul Composition bias and genome polarity of RNA viruses. Virus Research. Vol.109, No.1 (2005), 33-37. doi:10.1016/j.virusres.2004.10.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16394
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Composition bias and genome polarity of RNA viruses
Author(s)
Other Contributor(s)
Abstract
I have observed a relationship between GC content in coding sequences of RNA viruses and their genome polarity. Positive-stranded RNA viruses have significantly higher GC contents than negative-stranded RNA viruses. Coding sequences of all negative-stranded RNA viruses are biased toward high A in coding strands (high T in genomes), while two distinct patterns were observed among positive-stranded RNA genomes. This finding suggests that RNA viruses with different genome polarity are under different mutational pressure, which may be a consequence of the difference in the strategies of viral genome expression and replication. The GC content directly affects the viral codon adaptation index using highly expressed human genes as the reference set, which may theoretically predict the efficiency of viral gene expression in human cells. © 2004 Elsevier B.V. All rights reserved.