Publication: The association between HLA class II alleles and the occurrence of factor VIII inhibitor in Thai patients with hemophilia A
Issued Date
2012-04-09
Resource Type
ISSN
13085263
13007777
13007777
Other identifier(s)
2-s2.0-84859364107
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Mahidol University
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SCOPUS
Bibliographic Citation
Turkish Journal of Hematology. Vol.29, No.1 (2012), 34-39
Suggested Citation
Oytip Nathalang, Pramote Sriwanitchrak, Werasak Sasanakul, Ampaiwan Chuansumrit The association between HLA class II alleles and the occurrence of factor VIII inhibitor in Thai patients with hemophilia A. Turkish Journal of Hematology. Vol.29, No.1 (2012), 34-39. doi:10.5505/tjh.2012.29795 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/14839
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Title
The association between HLA class II alleles and the occurrence of factor VIII inhibitor in Thai patients with hemophilia A
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Abstract
Objective: This study aimed to investigate the association between HLA class II alleles and the occurrence of FVIII inhibitor in Thai hemophilia A patients. Material and Methods: The distribution of HLA-DRB1 alleles and DQB1 alleles in 57 Thai hemophilia A patients and 36 blood donors as controls was determined using the PCR sequence-specific primer (PCR-SSP) method, and the association between the occurrence of factor VIII (FVIII) inhibitor and the presence of certain HLA class II alleles was investigated. Results: The frequency of HLA-DRB1z.ast;15 was higher in the hemophilia A patients with and without FVIII inhibitor, whereas that of DRB1z.ast;14, DRB1z.ast;07, and DQB1z.ast;02 was lower in the hemophilia A patients with FVIII inhibitor, as compared to controls. Interestingly, only the frequency of DRB1z.ast;15 was significantly higher in the patients with inhibitor than in the controls (P = 0.021). Moreover, the frequency of DRB1z.ast;15 in the patients with inhibitor was higher than in those without inhibitor (P = 0.198). Conclusion: The study's findings show that the DRB1z.ast;15 allele might have contributed to the occurrence of inhibitor in the Thai hemophilia A patients; however, additional research using larger samples and high-resolution DRB1 typing is warranted.