Publication:
Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Issued Date

2016-11-01

Resource Type

Article

ISSN

18767753
18735061

DOI

10.1016/j.scr.2016.10.006

Other identifier(s)

2-s2.0-85028080077

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Stem Cell Research. Vol.17, No.3 (2016), 564-567

Suggested Citation

Natakarn Nimsanor, Ida Jørring, Mikkel A. Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Narisorn Kitiyanant, Jørgen E. Nielsen, Troels T. Nielsen, Poul Hyttel, Bjørn Holst, Benjamin Schmid Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia. Stem Cell Research. Vol.17, No.3 (2016), 564-567. doi:10.1016/j.scr.2016.10.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42863

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Title

Induced pluripotent stem cells (iPSCs) derived from a symptomatic carrier of a S305I mutation in the microtubule-associated protein tau (MAPT)-gene causing frontotemporal dementia

Author(s)

Natakarn Nimsanor
 Ida Jørring
 Mikkel A. Rasmussen
 Christian Clausen
 Ulrike A. Mau-Holzmann
 Narisorn Kitiyanant
 Jørgen E. Nielsen
 Troels T. Nielsen
 Poul Hyttel
 Bjørn Holst
 Benjamin Schmid

Other Contributor(s)

Bioneer AS
 Københavns Universitet
 Universität Tübingen
 Mahidol University

Abstract

© 2016 Michael Boutros, German Cancer Research Center, Heidelberg, Germany Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/42863

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Scopus 2016-2017