Publication: Serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive disease in Thai children younger than 5 years old, 2000-2005
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2007-01-26
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0264410X
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2-s2.0-33845883019
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Mahidol University
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SCOPUS
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Vaccine. Vol.25, No.7 (2007), 1275-1280
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Wanatpreeya Phongsamart, Somporn Srifeungfung, Surang Dejsirilert, Tanittha Chatsuwan, Pongpun Nunthapisud, Vipa Treerauthaweeraphong, Pimpha Rungnobhakhun, Kulkanya Chokephaibulkit Serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive disease in Thai children younger than 5 years old, 2000-2005. Vaccine. Vol.25, No.7 (2007), 1275-1280. doi:10.1016/j.vaccine.2006.10.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/24261
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Serotype distribution and antimicrobial susceptibility of S. pneumoniae causing invasive disease in Thai children younger than 5 years old, 2000-2005
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In order to predict the potential benefit of pneumococcal conjugate vaccines (PCV), we evaluated the serotype coverage of the 7-, 9-, 11- and 13-valent PCV over the isolates causing invasive pneumococcal disease (IPD) in Thai children. One hundred and fifteen Streptococcus pneumoniae isolates from sterile sites in children younger than 5 years old between 2000 and 2005 were serotyped. The coverages of 7-, 9-, 11-, and 13-valent PCV were 69%, 73.8%, 73.8% and 85.7% in children younger than 2 years, and 73.9%, 77.4%, 77.4% and 87.8% in children younger than 5 years of age, respectively. 69.6% and 22.6% of the isolates were non-susceptible to penicillin and cefotaxime. 7-valent PCV covered 89% and 100% of penicillin and cefotaxime non-susceptible isolates. © 2006 Elsevier Ltd. All rights reserved.