Publication: Immediate type hypersensitivity to chemotherapeutic agents in pediatric patients
Issued Date
2009-12-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-77953647798
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.27, No.4 (2009), 191-197
Suggested Citation
Nualanong Visitsunthorn, Wipa Utsawapreechawong, Punchama Pacharn, Orathai Jirapongsananuruk, Pakit Vichyanond Immediate type hypersensitivity to chemotherapeutic agents in pediatric patients. Asian Pacific Journal of Allergy and Immunology. Vol.27, No.4 (2009), 191-197. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27613
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Immediate type hypersensitivity to chemotherapeutic agents in pediatric patients
Other Contributor(s)
Abstract
Nine patients (3 boys and 6 girls) with a median age of 9.5 years, with immediate type hypersensitivity reactions to chemotherapeutic agents were reviewed. The presenting symptoms were urticaria (4/9) and anaphylaxis (5/9). The causative agents were vincristine (2/9), L asparaginase (2/9), mesna (1/9), cyclosporine (1/9), carboplatin (2/9) and cyclophosphamide (1/9). Three of the five patients with anaphylaxis were changed to alternative chemotherapeutic agents. In two cases alternative drugs were not available and the patients underwent safe and successful desensitization. Three of the 4 patients with urticaria were successfully exposed to graded challenges with cyclosporine, carboplatin and cyclophosphamide, respectively. In the other case with generalized urticaria, mesna was withdrawn due to a positive intradermal test. In patients with immediate type hypersensitivity reactions to chemotherapeutic drugs, if effective alternative chemotherapeutic agents are not available and/or the skin test is negative, a careful drug challenge and/or desensitization should be performed.