Publication: What can urinary exosomes tell us?
Issued Date
2021-04-01
Resource Type
ISSN
14209071
1420682X
1420682X
Other identifier(s)
2-s2.0-85099855239
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cellular and Molecular Life Sciences. Vol.78, No.7 (2021), 3265-3283
Suggested Citation
Rui Vitorino, Rita Ferreira, Sofia Guedes, Francisco Amado, Visith Thongboonkerd What can urinary exosomes tell us?. Cellular and Molecular Life Sciences. Vol.78, No.7 (2021), 3265-3283. doi:10.1007/s00018-020-03739-w Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76236
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Title
What can urinary exosomes tell us?
Abstract
Exosomes are involved in a wide variety of biochemical processes in human body homeostasis. Exosomes also provide important information regarding communications among several organ systems. Additionally, they can serve as molecular vehicles to deliver drugs. Therefore, exosomes have received wide attention in current biomedical research for unraveling pathogenic mechanisms of diseases, searching for novel biomarkers, and discovering new drugs. This paper reviews and discusses the significance of urinary exosomes for a better understanding of human disease pathophysiology and their potential use as therapeutic targets. Isolation methods of exosomes and the latest technological advances are also discussed. Furthermore, novel urinary exosomal biomarkers are highlighted with special emphasis on their clinical applicability (particularly sensitivity, specificity, reliability, and other aspects). Finally, future trends for this field are analyzed and our perspectives are provided.