Publication: Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
Issued Date
1989-06-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-0024675169
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.20, No.2 (1989), 201-205
Suggested Citation
P. Pitisuttithum, S. Migasena, P. Suntharasamai, W. Supanaranond, V. Desakorn, B. Prayurahong Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.. The Southeast Asian journal of tropical medicine and public health. Vol.20, No.2 (1989), 201-205. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15812
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Title
Immune responses following killed whole vibrio-B subunit oral cholera vaccine in human volunteers.
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Abstract
Immunogenicity of killed whole vibrio and B subunit oral cholera vaccines in American and Thai volunteers were analysed in terms of significant rise of antibody titre. Three doses of 2 x 10(11) killed vibrios and 5 mg of cholera toxin B subunit were given at two-week intervals. There were no differences in the percent of volunteers with significant rise of serum immunoglobulin G and secretory immunoglobulin A (sIgA) to cholera toxin. However, the percent with significant rises of serum antibody to whole cell V. cholerae Inaba measured by vibriocidal titre and serum immunoglobulin G, and secretory immunoglobulin A to lipopolysaccharide (LPS) measured by ELISA in American volunteers were significantly different from those in Thai volunteers (89% VS 45%, 68% VS 9% and 53% VS 0%, respectively) (p less than 0.05).