Publication: Non-Phenolic Linear Diarylheptanoids from Curcuma xanthorrhiza: A Novel Type of Topical Anti-Inflammatory Agents: Structure-Activity Relationship
Issued Date
1996-12-01
Resource Type
ISSN
00320943
Other identifier(s)
2-s2.0-0029977241
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.62, No.3 (1996), 236-240
Suggested Citation
P. Claeson, U. Pongprayoon, T. Sematong, P. Tuchinda, V. Reutrakul, P. Soontornsaratune, W. C. Taylor Non-Phenolic Linear Diarylheptanoids from Curcuma xanthorrhiza: A Novel Type of Topical Anti-Inflammatory Agents: Structure-Activity Relationship. Planta Medica. Vol.62, No.3 (1996), 236-240. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17530
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Title
Non-Phenolic Linear Diarylheptanoids from Curcuma xanthorrhiza: A Novel Type of Topical Anti-Inflammatory Agents: Structure-Activity Relationship
Abstract
The topical anti-inflammatory activity of three nonphenolic linear 1,7-diarylheptanoids, previously isolated from a Thai medicinal plant, Curcuma xonthorrhiza (Zingiberaceae) and four new semi-synthetic derivatives of the naturally occurring compounds were assessed in the murine model of ethyl phenylpropiolate-induced ear edema. The naturally occurring compound 1E,3E,1,7-diphenylheptadien-5-one (6) exerted the most potent anti-inflammatory activity, with an ID50 value of similar magnitude to that of the reference drug oxyphenbutazone (67 vs. 46 μg|ear, respectively). None of the semi-synthetic diarylheptanoids was more active than 6. The chemical structures and pharmacological data of the natural and semi-synthetic derivatives identified a distinct structure-activity relationship. The degree of unsaturation in positions 1 and 3, and the nature of the oxygenated functional group in position 5 of the C7-chain were found to play significant roles in determining the observed in vivo activity. Based on these findings, the non-phenolic linear 1,7-diarylheptanoids are proposed to represent a novel class of topical anti-inflammatory agents.