Publication: Locoregional recurrence in patients with HER2 positive breast cancer
Issued Date
2013-10-01
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ISSN
15323080
09609776
09609776
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2-s2.0-84884140983
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Mahidol University
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SCOPUS
Bibliographic Citation
Breast. Vol.22, No.5 (2013), 856-862
Suggested Citation
Janaina Brollo, Maximiliano Cassilha Kneubil, Edoardo Botteri, Nicole Rotmensz, Bruno Achutti Duso, Luca Fumagalli, Marzia Adelia Locatelli, Carmen Criscitiello, Visnu Lohsiriwat, Aron Goldhirsch, Maria Cristina Leonardi, Roberto Orecchia, Giuseppe Curigliano Locoregional recurrence in patients with HER2 positive breast cancer. Breast. Vol.22, No.5 (2013), 856-862. doi:10.1016/j.breast.2013.03.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32140
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Title
Locoregional recurrence in patients with HER2 positive breast cancer
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Abstract
Literature shows that HER2/neu positive breast cancer cells are more sensitive to radiation-induced apoptosis by targeting the epidermal growth factor receptor family tyrosine kinase. We selected 466 patients with pT1-2 HER2/neu positive tumors who received adjuvant trastuzumab for primary invasive breast cancer. Patients were divided into three groups [Quadrantectomy followed by conventional radiotherapy vsQuadrantectomy followed by Intra-operative radiotherapy with electrons vsMastectomy without radiotherapy]. After a median follow-up of 52 months, the 5-year cumulative incidence of locoregional recurrence (LRR) was 1.9%, 11.5% and 5.0% respectively ( p<0.01). At the multivariate analysis, extensive perivascular invasion, Luminal B HER2/Progesterone Receptor (PgR) negative status and Quadrantectomy followed by Intra-operative radiotherapy with electrons have significantly increased the risk of LRR. Our results suggest that HER2/neu positive breast cancer might have better outcomes when treated simultaneously with external radiotherapy and trastuzumab. Moreover, we underline the importance of PgR and further new stratification of risk among luminal subtypes. © 2013 Elsevier Ltd.