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Plant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stems

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dc.contributor.authorNorito Kanedaen_US
dc.contributor.authorJohn M. Pezzutoen_US
dc.contributor.authorDouglas Kinghornen_US
dc.contributor.authorNorman R. Farnsworthen_US
dc.contributor.authorThawatchai Santisuken_US
dc.contributor.authorPatoomratana Tuchindaen_US
dc.contributor.authorJinda Udchachonen_US
dc.contributor.authorVichai Reutrakulen_US
dc.contributor.otherUniversity of Illinois at Chicagoen_US
dc.contributor.otherThailand Royal Forest Departmenten_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-08-10T08:44:11Z
dc.date.available2018-08-10T08:44:11Z
dc.date.issued1992-05-01en_US
dc.description.abstractA new ring-A secotriterpene, koetjapic acid [1], and five known compounds, 3-oxo-olean-12-en-29-oic acid [2] (a novel natural product), katonic acid [3], (−)-alloaromadendrene, (−)-caryophyllene oxide, and (+)-spathulenol, have been isolated and characterized from a cytotoxic Et2O-soluble extract of Sandoricum koetjape stems. Of these compounds, 2 and 3 demonstrated significant cytotoxic activity against cultured P-388 cells (ED50values of 0.61 and 0.11 μg/ml, respectively). Significant, albeit less intense, cytotoxicity was also observed with a variety of cultured human cancer cells. The13C-nmr chemical shifts of these triterpenes were assigned unambiguously using selective INEPT nmr experiments. Aside from compounds 2 and 3, these substances were not toxic with cultured cells. © 1992, American Chemical Society. All rights reserved.en_US
dc.identifier.citationJournal of Natural Products. Vol.55, No.5 (1992), 654-659en_US
dc.identifier.doi10.1021/np50083a016en_US
dc.identifier.issn15206025en_US
dc.identifier.issn01633864en_US
dc.identifier.other2-s2.0-0026752589en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/22256
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026752589&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectChemistryen_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titlePlant anticancer agents, l. cytotoxic triterpenes from sandoricum koetjape stemsen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0026752589&origin=inwarden_US
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