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Diagnosis of Plasmodium vivax malaria using a specific deoxyribonucleic acid probe

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dc.contributor.authorWendy A. Relfen_US
dc.contributor.authorRobyn E. Borehamen_US
dc.contributor.authorPramuan Tapchaisrien_US
dc.contributor.authorSrisin Khusmithen_US
dc.contributor.authorAndrew Healeyen_US
dc.contributor.authorPeter Upcroften_US
dc.contributor.authorSavanat Tharavanijen_US
dc.contributor.authorChev Kidsonen_US
dc.contributor.otherQueensland Institute of Medical Researchen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-06-14T09:21:36Z
dc.date.available2018-06-14T09:21:36Z
dc.date.issued1990-01-01en_US
dc.description.abstractA deoxyribonucleic acid (DNA) probe which specifically distinguishes Plasmodium vivax from P. falciparum malaria has been derived from a P. vivax genomic DNA library. This probe, VPL101, consists of 3A 2 kilobase pairs and does not hybridize with up to 6 Ig of human or P. falciparum DNA. VPL101 contains at least two copies of a 205 base pair repeat sequence. The subcloned repeat probe, VPL101 5, reacted with 73 of 76 microscopically diagnosed P. vivax samples but not with any of 17 human DNA samples or any of 8 P. falciparum DNA samples from cultured parasites. It was possible to detect P. vivax in mixed infections in which only P. falciparum parasites were identifiable by microscopy. This P. vivax DNA probe provides a useful epidemiological tool for malaria control programmes. © 1990, Royal Society of Tropical Medicine and Hygiene. All Rights Reserved.en_US
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. Vol.84, No.5 (1990), 630-634en_US
dc.identifier.doi10.1016/0035-9203(90)90128-2en_US
dc.identifier.issn18783503en_US
dc.identifier.issn00359203en_US
dc.identifier.other2-s2.0-0025077615en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/15971
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025077615&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleDiagnosis of Plasmodium vivax malaria using a specific deoxyribonucleic acid probeen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0025077615&origin=inwarden_US

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