Publication: A modular framework for the development of targeted Covid-19 blood transcript profiling panels
Issued Date
2020-07-31
Resource Type
ISSN
14795876
Other identifier(s)
2-s2.0-85089116163
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of translational medicine. Vol.18, No.1 (2020), 291
Suggested Citation
Darawan Rinchai, Basirudeen Syed Ahamed Kabeer, Mohammed Toufiq, Zohreh Tatari-Calderone, Sara Deola, Tobias Brummaier, Mathieu Garand, Ricardo Branco, Nicole Baldwin, Mohamed Alfaki, Matthew C. Altman, Alberto Ballestrero, Matteo Bassetti, Gabriele Zoppoli, Andrea De Maria, Benjamin Tang, Davide Bedognetti, Damien Chaussabel A modular framework for the development of targeted Covid-19 blood transcript profiling panels. Journal of translational medicine. Vol.18, No.1 (2020), 291. doi:10.1186/s12967-020-02456-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/57696
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Title
A modular framework for the development of targeted Covid-19 blood transcript profiling panels
Author(s)
Darawan Rinchai
Basirudeen Syed Ahamed Kabeer
Mohammed Toufiq
Zohreh Tatari-Calderone
Sara Deola
Tobias Brummaier
Mathieu Garand
Ricardo Branco
Nicole Baldwin
Mohamed Alfaki
Matthew C. Altman
Alberto Ballestrero
Matteo Bassetti
Gabriele Zoppoli
Andrea De Maria
Benjamin Tang
Davide Bedognetti
Damien Chaussabel
Basirudeen Syed Ahamed Kabeer
Mohammed Toufiq
Zohreh Tatari-Calderone
Sara Deola
Tobias Brummaier
Mathieu Garand
Ricardo Branco
Nicole Baldwin
Mohamed Alfaki
Matthew C. Altman
Alberto Ballestrero
Matteo Bassetti
Gabriele Zoppoli
Andrea De Maria
Benjamin Tang
Davide Bedognetti
Damien Chaussabel
Other Contributor(s)
Ospedale Policlinico San Martino
Nepean Clinical School
Shoklo Malaria Research Unit
Benaroya Research Institute at Virginia Mason
Baylor Institute for Immunology Research
Università degli Studi di Genova
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
University of Washington, Seattle
Nuffield Department of Medicine
Sidra Medicine
Nepean Clinical School
Shoklo Malaria Research Unit
Benaroya Research Institute at Virginia Mason
Baylor Institute for Immunology Research
Università degli Studi di Genova
Universitat Basel
Swiss Tropical and Public Health Institute (Swiss TPH)
University of Washington, Seattle
Nuffield Department of Medicine
Sidra Medicine
Abstract
BACKGROUND: Covid-19 morbidity and mortality are associated with a dysregulated immune response. Tools are needed to enhance existing immune profiling capabilities in affected patients. Here we aimed to develop an approach to support the design of targeted blood transcriptome panels for profiling the immune response to SARS-CoV-2 infection. METHODS: We designed a pool of candidates based on a pre-existing and well-characterized repertoire of blood transcriptional modules. Available Covid-19 blood transcriptome data was also used to guide this process. Further selection steps relied on expert curation. Additionally, we developed several custom web applications to support the evaluation of candidates. RESULTS: As a proof of principle, we designed three targeted blood transcript panels, each with a different translational connotation: immunological relevance, therapeutic development relevance and SARS biology relevance. CONCLUSION: Altogether the work presented here may contribute to the future expansion of immune profiling capabilities via targeted profiling of blood transcript abundance in Covid-19 patients.