Publication:
Within-host evolutionary dynamics of seasonal and pandemic human influenza a viruses in young children

Issued Date

2021-01-01

Resource Type

Article

ISSN

2050084X

DOI

10.7554/ELIFE.68917

Other identifier(s)

2-s2.0-85112443339

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

eLife. Vol.10, (2021)

Suggested Citation

Alvin X. Han, Zandra C.Felix Garza, Matthijs R.A. Welkers, René M. Vigeveno, Tran Nhu Duong, Le Thi Quynh Mai, Pham Quang Thai, Dang Dinh Thoang, Tran Thi Ngoc Anh, Ha Manh Tuan, Nguyen Thanh Hung, Le Quoc Thinh, Le Thanh Hai, Hoang Thi Bich Ngoc, Kulkanya Chokephaibulkit, Pilaipan Puthavathana, Nguyen Van Vinh Chau, Nghiem My Ngoc, Nguyen Van Kinh, Dao Tuyet Trinh, Tran Tinh Hien, Heiman F.L. Wertheim, Peter Horby, Annette Fox, H. Rogier van Doorn, Dirk Eggink, Menno D. de Jong, Colin A. Russell Within-host evolutionary dynamics of seasonal and pandemic human influenza a viruses in young children. eLife. Vol.10, (2021). doi:10.7554/ELIFE.68917 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76349

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Thesis

Title

Within-host evolutionary dynamics of seasonal and pandemic human influenza a viruses in young children

Author(s)

Alvin X. Han
 Zandra C.Felix Garza
 Matthijs R.A. Welkers
 René M. Vigeveno
 Tran Nhu Duong
 Le Thi Quynh Mai
 Pham Quang Thai
 Dang Dinh Thoang
 Tran Thi Ngoc Anh
 Ha Manh Tuan
 Nguyen Thanh Hung
 Le Quoc Thinh
 Le Thanh Hai
 Hoang Thi Bich Ngoc
 Kulkanya Chokephaibulkit
 Pilaipan Puthavathana
 Nguyen Van Vinh Chau
 Nghiem My Ngoc
 Nguyen Van Kinh
 Dao Tuyet Trinh
 Tran Tinh Hien
 Heiman F.L. Wertheim
 Peter Horby
 Annette Fox
 H. Rogier van Doorn
 Dirk Eggink
 Menno D. de Jong
 Colin A. Russell

Other Contributor(s)

Siriraj Hospital
 Oxford University Clinical Research Unit
 World Health Organization, Australia
 National Institute of Hygiene and Epidemiology Hanoi
 University of Melbourne
 National Institute for Public Health and the Environment
 University College London Hospitals NHS Foundation Trust
 Nuffield Department of Medicine
 Radboud University Medical Center
 Amsterdam UMC - University of Amsterdam
 Ha Nam Centre for Preventive Medicine
 Vietnam National Children's Hospital
 National Hospital for Tropical Diseases
 Children's Hospital 2
 Children's Hospital 1

Abstract

The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on infections in healthy adults based on single timepoint data. Here, we analysed the within-host evolution of 82 longitudinally-sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 viruses between 2007 and 2009. For A/H1N1pdm09 infections during the 2009 pandemic, nonsynonymous minority variants were more prevalent than synonymous ones. For A/H3N2 viruses in young children, early infection was dominated by purifying selection. As these infections progressed, nonsynonymous variants typically increased in frequency even when within-host virus titres decreased. Unlike the short-lived infections of adults where de novo within-host variants are rare, longer infections in young children allow for the maintenance of virus diversity via mutation-selection balance creating potentially important opportunities for within-host virus evolution.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology
 Neuroscience

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/76349

Collections

Scopus 2021