Publication: Treatment outcomes and clinical relevance in patients with double expressor DLBCL
Issued Date
2021-01-01
Resource Type
ISSN
20353006
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2-s2.0-85119482951
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Mahidol University
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SCOPUS
Bibliographic Citation
Mediterranean Journal of Hematology and Infectious Diseases. Vol.13, No.1 (2021)
Suggested Citation
Sirapat Rungwittayatiwat, Paisarn Boonsakan, Pichika Chantrathammachart, Teeraya Puavilai, Sulada Pukiat, Sithakom Phusanti, Kochawan Boonyawat, Pathawut Wacharapornin, Pantep Angchaisuksiri, Artit Ungkanont, Suporn Chuncharunee, Pimjai Niparuck Treatment outcomes and clinical relevance in patients with double expressor DLBCL. Mediterranean Journal of Hematology and Infectious Diseases. Vol.13, No.1 (2021). doi:10.4084/MJHID.2021.063 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78564
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Title
Treatment outcomes and clinical relevance in patients with double expressor DLBCL
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Abstract
Background: Double-expressor lymphoma (DEL) was found to account for 20- 30% of DLBCL. We conducted this study to analyze the survival, the clinical presentation, and the factors associated with treatment outcomes in DEL-DLBCL. Methods: A retrospective study of 291 patients diagnosed with DLBCL during January 2015 - December 2018 was conducted. Results: Of the 291 patients, the median age was 63 years, germinal center B cell-like DLBCL (GCB) and non-GCB subtypes were found in 32% and 68%, respectively. DEL was found in 46% of 264 patients with available immunohistochemistry staining for MYC protein. Patients with DEL was significantly more common in elderly patients (p= 0.017) and non-GCB subtype (p= 0.006). High serum lactate dehydrogenase (LDH) levels and high Ki-67 index were significantly found in DEL patients than non-DEL patients (p= 0.024 and p= 0.04, respectively). The 3y-OS rate was shorter in the DEL group than in the non-DEL group, 58.7% versus 78.9% (p=0.026), whereas no significant difference in 3y-DFS was identified between these groups (58.4% versus 67.7%, p= 0.343). Independent factors affecting OS and DFS in DEL patients were ECOG 3-4, high LDH levels, extranodal involvement> 1 site, high IPI, and stage III-IV in univariate analysis. Conclusions: High incidence of DEL was observed in this study, especially in patients aged 60 years or older and non-GCB subtype. Patients with DEL showed dismal DFS and OS.