Publication: Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis
Issued Date
2020-01-01
Resource Type
ISSN
17565391
17565383
17565383
Other identifier(s)
2-s2.0-85085123452
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Evidence-Based Medicine. (2020)
Suggested Citation
Kanhatai Chiengthong, Wisit Cheungpasitporn, Charat Thongprayoon, Ploypin Lertjitbanjong, Liam D. Cato, Tarun Bathini, Patompong Ungprasert, Michael A. Mao, Ronpichai Chokesuwattanaskul Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis. Journal of Evidence-Based Medicine. (2020). doi:10.1111/jebm.12383 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/56331
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Vitamin D deficiency is not associated with graft versus host disease after hematopoietic stem cell transplantation: A meta-analysis
Other Contributor(s)
University Hospital Birmingham NHS Foundation Trust
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Faculty of Medicine, Siriraj Hospital, Mahidol University
The University of Arizona
Mayo Clinic
University of Mississippi Medical Center
The Mary Imogene Bassett Hospital
Mayo Clinic in Jacksonville, Florida
King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University
Faculty of Medicine, Siriraj Hospital, Mahidol University
The University of Arizona
Mayo Clinic
University of Mississippi Medical Center
The Mary Imogene Bassett Hospital
Mayo Clinic in Jacksonville, Florida
Abstract
© 2020 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd Objective: Vitamin D status plays an important role in immunoregulation, and a deficiency is believed to be related to Graft Versus Host Disease (GVHD) in patients after hematopoietic stem cell transplantation (HSCT). We aim to study the association between vitamin D deficiency and GVHD after HSCT. Methods: A literature search was conducted utilizing MEDLINE, EMBASE, and The Cochrane Library Database from inception to July 2019. Eligible studies were required to1 be clinical trials or observational studies (cohort, case-control, or cross-sectional studies);2 provide data to calculate the odds ratios (OR) of GVHD in HSCT patients with vitamin D deficiency. Two reviewers independently extracted the data and assessed the risk of bias. Pooled odds ratios (OR) with 95% confidence interval (CI) were estimated using random-effects meta-analysis through the Comprehensive Meta-Analysis 3.3 software. Results: In total, 8 observational studies consisting of 1335 HSCT patients were enrolled in this systematic review. Overall, there was no significant association between vitamin D deficiency and acute GVHD (OR = 1.06, 95% CI 0.74-1.53, P > 0.05). There was no significant association between vitamin D deficiency and chronic GVHD (OR = 1.75, 95% CI 0.72-4.26, P > 0.05). Funnel plots and Egger regression asymmetry test were performed and showed no publication bias. Conclusion: There is not a statistically significant association between vitamin D deficiency and neither acute nor chronic GVHD.