Publication: Atorvastatin attenuates TLR4-mediated NF-κB activation in a MyD88-dependent pathway
Issued Date
2009-08-03
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ISSN
0125877X
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2-s2.0-67749122584
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.27, No.1 (2009), 49-57
Suggested Citation
Praveen Chansrichavala, Udom Chantharaksri, Piyamitr Sritara, Sansanee C. Chaiyaroj Atorvastatin attenuates TLR4-mediated NF-κB activation in a MyD88-dependent pathway. Asian Pacific Journal of Allergy and Immunology. Vol.27, No.1 (2009), 49-57. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27679
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Title
Atorvastatin attenuates TLR4-mediated NF-κB activation in a MyD88-dependent pathway
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Abstract
Antigen presenting cells such as dendritic cells and macrophages have recently been detected in atherosclerotic plaques. Toll-like receptors expressed on the surface of these cells, have been implicated in ongoing inflammatory responses in the plaques. In this study, we investigated the anti-inflammatory effect of atorvastatin, a lipid lowering drug, via Toll-like receptor 4 (TLR4) in vitro, employing murine pro-B cell lines transfected with hTLR4/MD2 and MyD88/hTLR4/MD2 systems. The results showed that atorvastatin at 10 μM significantly attenuated NF-κB activation within 24 hours while at lower doses of 0.1 and 1 μM, treatment time had to be prolonged up to 48 hours for a significant inhibition to occur. The inhibition of NF-κB was also observed in a cell line cotransfected with MyD88 and TLR4 suggesting that the attenuation of NF-κB by atorvastatin occurred in a MyD88 dependent fashion.