Publication: Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy
Issued Date
2007-04-25
Resource Type
ISSN
10960341
00426822
00426822
Other identifier(s)
2-s2.0-34147092694
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virology. Vol.361, No.1 (2007), 80-92
Suggested Citation
Gilda Grard, Grégory Moureau, Rémi N. Charrel, Jean Jacques Lemasson, Jean Paul Gonzalez, Pierre Gallian, Tamara S. Gritsun, Edward C. Holmes, Ernest A. Gould, Xavier de Lamballerie Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy. Virology. Vol.361, No.1 (2007), 80-92. doi:10.1016/j.virol.2006.09.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24559
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy
Abstract
Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages. © 2006 Elsevier Inc. All rights reserved.