Publication: The role of melatonin in targeting cell signaling pathways in neurodegeneration
Issued Date
2019-05-01
Resource Type
ISSN
17496632
00778923
00778923
Other identifier(s)
2-s2.0-85061477802
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of the New York Academy of Sciences. Vol.1443, No.1 (2019), 75-96
Suggested Citation
Mayuri Shukla, Vorapin Chinchalongporn, Piyarat Govitrapong, Russel J. Reiter The role of melatonin in targeting cell signaling pathways in neurodegeneration. Annals of the New York Academy of Sciences. Vol.1443, No.1 (2019), 75-96. doi:10.1111/nyas.14005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49949
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The role of melatonin in targeting cell signaling pathways in neurodegeneration
Abstract
© 2019 New York Academy of Sciences. Neurodegenerative diseases are typified by neuronal loss associated with progressive dysfunction and clinical presentation. Neurodegenerative diseases are characterized by the intra- and extracellular conglomeration of misfolded proteins that occur because of abnormal protein dynamics and genetic manipulations; these trigger processes of cell death in these disorders. The disrupted signaling mechanisms involved are oxidative stress–mediated mitochondrial and calcium signaling deregulation, alterations in immune and inflammatory signaling, disruption of autophagic integrity, proteostasis dysfunction, and anomalies in the insulin, Notch, and Wnt/β-catenin signaling pathways. Herein, we accentuate some of the contemporary translational approaches made in characterizing the underlying mechanisms of neurodegeneration. Melatonin-induced cognitive enhancement and inhibition of oxidative signaling substantiates the efficacy of melatonin in combating neurodegenerative processes. Our review considers in detail the possible roles of melatonin in understanding the synergistic pathogenic mechanisms between aggregated proteins and in regulating, modulating, and preventing the altered signaling mechanisms discovered in cellular and animal models along with clinical evaluations pertaining to neurodegeneration. Furthermore, this review showcases the therapeutic potential of melatonin in preventing and treating neurodegenerative diseases with optimum prognosis.